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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1548-1551. 上一篇    下一篇

研究论文

金属氯化物对硼氢化钠还原α-氯代苯乙酮的影响

王明慧，吴坚平，杨立荣*，陈新志   

  1. (浙江大学化学与生物工程学系 杭州 310027)
  • 收稿日期:2005-06-17 修回日期:2005-06-07 发布日期:2005-11-30
  • 通讯作者: 杨立荣

Effect of Metal Chlorides on the Reduction of α-Chloroacetophenones with Sodium Borohydride

WANG Ming-Hui, WU Jian-Ping, YANG Li-Rong*, CHEN Xin-Zhi   

  1. (Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027)
  • Received:2005-06-17 Revised:2005-06-07 Published:2005-11-30
  • Contact: YANG Li-Rong

用NaBH4还原α-氯代苯乙酮制备相应的β-氯代-α-苯乙醇时, 在较高的反应温度下产生许多副产物, 钙、镧、镁、锰、锌等金属氯化物的存在能有效抑制副反应的发生, 高产率地得到产物.

关键词: β-氯代-α-苯乙醇, 金属氯化物, α-氯代苯乙酮, 硼氢化钠, 还原

During the synthesis of β-chloro-α-phenylethanols by reduction of α-chloroacetophenones with sodium borohydride, many byproducts were produced unavoidably at relatively high temperature. Metal chlorides such as calcium, lanthanum, magnesium, manganese and zinc chloride could efficiently restrain side reactions, and so the product was obtained in high yield.

Key words: α-chloroacetophenone, metal chloride, sodium borohydride, reduction, β-chloro-α-phenylethanol