有机化学 ›› 2011, Vol. 31 ›› Issue (04): 505-510. 上一篇    下一篇

研究论文

轴不安定性联苯类膦-噁唑啉配体/铱配合物在亚胺不对称氢化反应中的应用

姚冬梅,田丰涛,张万斌*   

  1. (上海交通大学化学化工学院 上海 200240)
  • 收稿日期:2010-08-10 修回日期:2010-11-23 发布日期:2010-11-23
  • 通讯作者: 张万斌 E-mail:wanbin@sjtu.edu.cn

Asymmetric Hydrogenation of Imines Catalyzed by Ir/Phosphine- oxazoline Complexes with an Axis-unfixed Biphenyl Backbone

YAO Dong-Mei, TIAN Feng-Tao, ZHANG Wan-Bin   

  1. (School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240)
  • Received:2010-08-10 Revised:2010-11-23 Published:2010-11-23

考察了一系列轴不安定性联苯类膦-噁唑啉配体/铱配合物作为手性催化剂用于亚胺类底物的不对称催化氢化反应. 结果表明该类催化剂具有很高的催化活性(99%转化率)和较好的对映选择性(75% ee).

关键词: 轴手性, 膦-噁唑啉配体, 铱配合物, 不对称氢化, 亚胺

A series of Ir complexes with axis-unfixed phosphine-oxazoline ligands were applied as catalysts in the asymmetric hydrogenation of imines. It was found that these catalysts showed excellent catalytic activity (up to 99% conversion) and good enantioselectivity (up to 75% ee) for the reaction.

Key words: axial chirality, phosphine-oxazoline ligand, Ir complex, asymmetric hydrogenation, imine