有机化学 ›› 2012, Vol. 32 ›› Issue (06): 1024-1040.DOI: 10.6023/cjoc1110313 上一篇    下一篇

综述与进展

偶氮二甲酸酯在有机合成中的研究进展

许孝良, 程国华, 李小年   

  1. 浙江工业大学化学工程与材料学院 杭州 310032
  • 收稿日期:2011-10-31 修回日期:2011-12-16 发布日期:2011-01-06
  • 通讯作者: 许孝良, 李小年 E-mail:xuxiaoliang@zjut.edu.cn; xnli@zjut.edu.cn
  • 基金资助:
    国家自然科学基金(No. 20872131)资助项目.

Application of Azodicarboxylates in Organic Synthesis

Xu Xiaoliang, Cheng Guohua, Li Xiaonian   

  1. College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310032
  • Received:2011-10-31 Revised:2011-12-16 Published:2011-01-06
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 20872131).

偶氮二甲酸酯由于具有独特的电子和结构特性, 作为一种多功能化的试剂在有机合成中得到了广泛的应用. 特别是在Mitsunobu 反应、羰基化合物的氨化、不饱烃的氨化及杂环化合物的合成中有着非常重要的作用, 此外偶氮二甲酸酯还可以作为氧化剂, 用于醇、胺的脱氢氧化反应. 回顾了其在有机合成中原有的应用基础之上, 对其近年来在合成化学中的新发展进行了综述, 并对其发展加以展望.

关键词: 偶氮二甲酸酯, 有机合成, 碳氮键形成

Azodicarboxylates, as versatile reagents, have been widely used in organic synthesis due to their unique electronic and structural properties. They have played important roles in organic synthesis such as Mitsunobu reaction, amination of carbonyl compounds and unsaturated hydrocarbons, synthesis of heterocyclic compounds. Besides these, azodicarboxylates can be used as oxidants for the dehydrogenation of alcohols and amines. Based on their previous applications, new progress of azodicarboxylates in synthetic chemistry in recent years is summarized and an outlook on their development is also given.

Key words: azodicarboxylates, organic synthesis, C—N bond formation