有机化学 ›› 2013, Vol. 33 ›› Issue (06): 1235-1243.DOI: 10.6023/cjoc201303044 上一篇    下一篇

综述与进展

达菲合成最新进展

张田财, 鲁慧, 张辅民, 程军, 刘天阳   

  1. 兰州大学功能有机分子化学国家重点实验室 兰州大学化学化工学院 兰州 730000
  • 收稿日期:2013-03-27 修回日期:2013-05-09 发布日期:2013-05-13
  • 通讯作者: 张辅民 E-mail:zhangfm@lzu.edu.cn
  • 基金资助:

    国家自然科学基金委(Nos.20972059, 21290180);教育部长江学者创新团队(No.IRT1138)和中央高校基本科研费(No.lzujbky-2013-ct02)资助项目.

Recent Progress in the Synthesis of Tamiflu

Zhang Tiancai, Lu Hui, Zhang Fu-Min, Cheng Jun, Liu Tianyang   

  1. State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000
  • Received:2013-03-27 Revised:2013-05-09 Published:2013-05-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.20972059, 21290180), the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT1138) and the Fundamental Research Funds for the Central Universities (No.lzujbky-2013-ct02).

作为预防和治疗各种流感的首选药物, 达菲的合成受到化学合成工作者的广泛关注.4年来, 涌现出了多条极具特色的合成路线, 将对这些合成路线做一综述.

关键词: 达菲, 药物, 全合成

Tamiflu, one of the most common orally drugs for the treatment and prevention of influenza, has attracted extensive interests of synthetic chemists all over the world.Concise, efficient, and scalable synthetic approaches toward this molecule have been a very active field in recent years, and many diverse synthetic routes have been developed to date.In this review, representative synthetic routes employing chiral starting material or catalytic asymmetric reactions are briefly summarized.

Key words: tamiflu, drug, total synthesis