有机化学 ›› 2013, Vol. 33 ›› Issue (12): 2443-2459.DOI: 10.6023/cjoc201308023 上一篇    下一篇

综述与进展

白藜芦醇低聚物的化学选择性合成

李文玲, 吕腾, 杨玉华, 杨亚东   

  1. 兰州交通大学化学与生物工程学院 兰州 730070
  • 收稿日期:2013-08-19 修回日期:2013-09-27 发布日期:2013-09-30
  • 通讯作者: 李文玲 E-mail:liwl@mail.lzjtu.cn
  • 基金资助:

    国家自然科学基金(No. 21062010)、兰州交通大学青蓝人才工程基金(No. QL-08-06A)资助项目.

Chemoselectively Synthesis of Resveratrol Oligomers

Li Wenling, Lü Teng, Yang Yuhua, Yang Yadong   

  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070
  • Received:2013-08-19 Revised:2013-09-27 Published:2013-09-30
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21062010), the "Qing Lan" Talent Engineering Funds of Lanzhou Jiaotong University (No. QL-08-06A).

白藜芦醇低聚物是单体在生物酶作用下相互偶合而形成的一类多酚化合物,从生源途径出发的仿生合成法在过去30多年得到了广泛研究,近年来,应用各种新颖的高化学选择性的串联反应来构建此类低聚物的复杂结构已成为一个新的研究热点,目前多数集中于消旋物的化学合成,不对称合成研究才刚刚起步. 介绍了近7年来国内外有关白藜芦醇低聚物的化学合成方法,并对目前研究中存在的问题和今后发展方向进行了探讨.

关键词: 白藜芦醇, 低聚, 化学选择性, 全合成

Resveratrol oligomers are a class of plant polyphenols which are formed in nature by oxidative oligomerization of resveratrol catalyzed by enzymes and have received considerable attention of synthetic chemists on account of their structural complexity and diverse biological activities. The biomimetic synthetic strategy based on the oxidative coupling reaction has been extensively studied over the past thirty years, but the lacks of regio-or stereo-selectivity impose restrictions on its universal application. Recently, The synthetic efforts on the diverse skeletons of these oligomers through novel and effective cascade reactions has been a hot research topic and have achieved dramatic success. And they were mostly focused on the synthesis of racemates and the asymmetric synthesis research on these oligomers has just started. In this paper, the progress in the chemical syntheses of resveratrol oligomers in recent seven years is reviewed in detail and the future synthetic trend of oligostilbenes is also prospected.

Key words: resveratrol, oligomerization, chemoselectivity, total synthesis