有机化学 ›› 2019, Vol. 39 ›› Issue (4): 883-902.DOI: 10.6023/cjoc201808039 上一篇    下一篇

所属专题: 碳氢活化合辑2018-2019

综述与进展

金属催化剂催化醇和胺直接偶联制备亚胺的研究进展

王辉, 黄龙江   

  1. 青岛科技大学化工学院 青岛 266042
  • 收稿日期:2018-08-30 修回日期:2018-11-14 发布日期:2018-12-05
  • 通讯作者: 黄龙江 E-mail:huanglj@qust.edu.cn
  • 基金资助:

    山东省高等教育科技计划(No.J16LC13)资助项目.

Progress in Imine Formation from Direct Coupling of Alcohols and Amines Catalyzed by Metal Catalysts

Wang Hui, Huang Longjiang   

  1. College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042
  • Received:2018-08-30 Revised:2018-11-14 Published:2018-12-05
  • Contact: 10.6023/cjoc201808039 E-mail:huanglj@qust.edu.cn
  • Supported by:

    Project supported by the Higher Educational Science and Technology Program of Shandong Province (No. J16LC13).

亚胺又称席夫碱,广泛存在于天然产物、生物活性化合物和药物等分子结构中.亚胺中的C=N双键具有较高的反应活性,可作为氮源应用于不同类型的反应中,因此在生物、医药、染料和材料等方面都有重要应用.金属催化剂催化醇胺直接偶联制备亚胺因具有原子经济性高、绿色环保等优点,近年来获得了广泛关注并取得了重要进展.系统地总结和评述了近年来金属催化剂催化醇和胺直接偶联制备亚胺反应的研究进展,并对其未来发展方向进行了展望.

关键词: 亚胺, 醇, 胺, 金属催化

Imines are very important class of compounds and have been widely utilized in fine chemicals, pharmaceuticals and chemical industry. The C=N double bond in imine is an important nitrogen source in different types of reactions due to its high reactive activity. Due to its high atom economy, catalytic direct coupling of alcohols and amines to imines based on metal catalysts has attracted much attention and maken great progress in recent years. In this paper, the advances in direct coupling of alcohols and amines to imines catalyzed by metal catalysts are reviewed.

Key words: imine, alocohols, amines, metal catalysis