氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3＋2]环加成反应:螺吡唑类化合物的合成

doi:10.6023/cjoc201907030

摘要/Abstract

采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的[3＋2]环加成反应，在温和条件下，以高产率（78%～94%）和高非对映选择性（>20∶1 dr）构建了一系列具有螺环结构的吡唑类化合物.

The[3+2] cycloaddition of methylenedihydrobenzofurandiones and nitrilimines worked efficiently in CHCl₃ at room temperature in the presence of Et₃N, producing biologically interesting spirocyclic pyrazole derivatives in high yield (78%~94%) with excellent diastereoselectivity.

Key words: cycloaddition, nitrilimine, spirocyclic compound, pyrazole

引用此文

史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超. 氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3＋2]环加成反应:螺吡唑类化合物的合成[J]. 有机化学, 2020, 40(3): 756-762.

Shi Wangyu, Xu Jiaqing, Mao Biming, Jia Hao, Huang Jiaxing, Guo Hongchao. [3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds[J]. Chinese Journal of Organic Chemistry, 2020, 40(3): 756-762.

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