有机化学 ›› 2020, Vol. 40 ›› Issue (10): 3289-3299.DOI: 10.6023/cjoc202003014 上一篇    下一篇

所属专题: 黄乃正院士七十华诞专辑

综述与进展

天然产物Gracilioethers和Hippolachnin A的合成研究进展

吴璟华, 王诚, 陈鹏全, 马志强   

  1. 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510641
  • 收稿日期:2020-03-06 修回日期:2020-04-08 发布日期:2020-04-17
  • 通讯作者: 马志强 E-mail:cezqma@scut.edu.cn
  • 基金资助:
    国家重点研发计划(No.2016YFA0602900)、广州市科技计划(No.201707010073)和国家自然科学基金(Nos.21672073,21871098)资助项目.

Synthetic Progress of Natural Products Gracilioethers and Hippolachnin A

Wu Jinghua, Wang Cheng, Chen Pengquan, Ma Zhiqiang   

  1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641
  • Received:2020-03-06 Revised:2020-04-08 Published:2020-04-17
  • Supported by:
    Project supported by the National Program on Key Research Project (No. 2016YFA0602900), the Science and Technology Program of Guangzhou City (No. 201707010073) and the National Natural Science Foundation of China (Nos. 21672073, 21871098).

Gracilioether家族天然产物与hippolachnin A都是从海洋海绵中分离得到的.Gracilioether家族天然产物具有良好的抗疟疾活性,而hippolachnin A具有良好的抗菌活性.它们有趣的结构和良好的生物活性吸引了化学家的关注.按照合成的策略分类,概括了gracilioether家族中具有三环骨架结构的天然产物和hippolachnin A的全合成研究.

关键词: gracilioether, hippolachnin A, 天然产物, 全合成

Gracilioethers and hippolachnin A were isolated from marine sponge. Gracilioethers showed antimalarial activity while hippolachnin A exhibited strong antifungal activity. Their fascinating structures and outstanding biological activities have attracted attentions from chemists. Progress on the synthesis of gracilioethers with tricyclic skeleton and hippolachnin A are reviewed in terms of the key strategies employed.

Key words: gracilioether, hippolachnin A, natural product, total synthesis