有机化学 ›› 2021, Vol. 41 ›› Issue (5): 2038-2044.DOI: 10.6023/cjoc202011014 上一篇    下一篇

研究论文

乙酸铵催化的酚与多聚甲醛的甲酰化反应研究

李倩1, 杨丽1, 刘伟1, 王天昀1, 朱月杰1, 杜正银1,*()   

  1. 1 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2020-11-09 修回日期:2020-12-26 发布日期:2021-02-07
  • 通讯作者: 杜正银
  • 基金资助:
    国家自然科学基金(21262028); 国家自然科学基金(21762039); 甘肃省自然科学基金(20JR5RA521)

Formylation of Phenols and Paraformaldehyde Catalyzed by Ammonium Acetate

Qian Li1, Li Yang1, Wei Liu1, Tianyun Wang1, Yuejie Zhu1, Zhengyin Du1,*()   

  1. 1 College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2020-11-09 Revised:2020-12-26 Published:2021-02-07
  • Contact: Zhengyin Du
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    National Natural Science Foundation of China(21262028); National Natural Science Foundation of China(21762039); Natural Science Foundation of Gansu Province(20JR5RA521)

在乙酸铵作为催化剂的条件下, 萘酚和多聚甲醛在醋酸溶液中反应, 成功合成了一系列羟基萘甲醛, 收率最高达86%. 将该方法应用于苯酚及取代苯酚的甲酰化反应, 以42%~58%的中等收率得到水杨醛类化合物. 根据反应结果提出了可能的作用机理. 该方法不使用任何金属试剂, 具有反应条件温和、操作简单及成本低廉的特点.

关键词: 萘酚, 苯酚, 多聚甲醛, 甲酰化反应, 绿色合成

The reaction of naphthol and paraformaldehyde in acetic acid solution with ammonium acetate as a catalyst resulted in the synthesis of a series of hydroxynaphthalenes in yields of up to 86%. Several phenols were also transformed into the corresponding salicylaldehydes under the same reaction conditions in moderate yields of 42%~58%. A rational mechanism was also proposed based on the facts of experimental observations. This metal-free process has the advantages of mild reaction conditions, simple operation and low cost.

Key words: naphthol, phenol, paraformaldehyde, formylation reaction, green synthesis