有机化学 ›› 2022, Vol. 42 ›› Issue (10): 3129-3142.DOI: 10.6023/cjoc202208024 上一篇    下一篇

所属专题: 不对称催化专辑

综述与进展

手性膦催化的氮杂环合成研究进展

任红霞, 马萌萌, 黄有*()   

  1. 南开大学化学学院 元素有机化学国家重点实验室 天津 300071
  • 收稿日期:2022-08-19 修回日期:2022-10-11 发布日期:2022-11-02
  • 通讯作者: 黄有
  • 基金资助:
    国家自然科学基金(22171147); 国家自然科学基金(21871148); 国家自然科学基金(21672109)

Progress in Synthesis of Nitrogen Heterocycles Catalyzed by Chiral Phosphine

Hongxia Ren, Mengmeng Ma, You Huang()   

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071
  • Received:2022-08-19 Revised:2022-10-11 Published:2022-11-02
  • Contact: You Huang
  • About author:
    Dedicated to the 60th anniversary of Institute of Elemento-Organic Chemistry at Nankai University.
  • Supported by:
    National Natural Science Foundation of China(22171147); National Natural Science Foundation of China(21871148); National Natural Science Foundation of China(21672109)

手性氮杂环是一类重要的有机分子, 这类骨架广泛存在于药物、农药以及许多具有生物活性的天然产物分子中, 手性含氮杂环的合成是有机合成化学中的重要研究领域, 有机催化反应是合成氮杂环的重要方法, 在这些方法中, 手性有机膦催化的氮杂环的合成被证明是一个实用且强大的方法. 对近年来手性膦催化的氮杂环的合成反应进行了综述, 并对该领域的发展方向进行了展望.

关键词: 手性膦催化剂, 有机催化, 环化反应, 手性氮杂环

Chiral aza-heterocycles are important molecular skeletons of organic chemistry, which are extensively found in pharmaceuticals, pesticides and biologically active natural products. As a significant organic chemistry research filed, the development of efficient novel synthetic methods of them has been a challenge. Among these strategies for the synthesis of aza-heterocycles compounds, chiral phosphine organocatalysis provides a practical and powerful platform. The recent progress in synthesis of chiral nitrogen heterocycles catalyzed by chiral phosphine is summarized, and the development of this field is also prospected.

Key words: chiral phosphine catalyst, organocatalysis, annulation reaction, chiral N-heterocycle