过渡金属催化氮原子α位Csp3-H键官能团化反应研究进展

doi:10.6023/cjoc202404040

摘要/Abstract

在有机合成化学中,C-H键的官能团化是一个十分重要的研究领域. 在众多处于不同化学环境的C-H键中N-α位的C_sp3-H键因氮原子的诱导效应使其相较于其他的C_sp3-H键具有更高的活性, 并且在氮原子的诱导效应下N-α位C_sp3-H键的区域选择性官能团化也因为氮原子的诱导可以更好的实现, 因此氮原子α位C_sp3-H键官能团化是一种非常实用的合成策略, 这为含有氮原子的有机化合物（如尼可刹米、奎宁）的合成和开发提供了更多可能. 本文综述了近二十年来氮原子的α位C_sp3-H键官能团化的发展现状并展望此方法在以后的潜力.

关键词: 氮原子, 官能团化, C_sp3-H, 过渡金属

Functionalization of C-H bonds is a very important research area in organic synthetic chemistry. In many C-H bonds located in different chemical environments, the induced effect of the nitrogen atom at the N-α C_sp3-H position makes the α C_sp3-H bond more active compared to other C_sp3-H bonds, and the regioselective functionalization of the α C_sp3-H bond is also better achieved with the help of the nitrogen atom. Therefore, the functionalization of the α C_sp3-H bond of nitrogen atoms is a very practical synthetic strategy, this provides more possibilities for the synthesis and development of organic compounds containing nitrogen atoms (such as nicotinamide and quinine). This article reviews the current development of functionalization of the α C_sp3-H bond of nitrogen atoms in the past twenty years and looks forward to the potential of this method in the future.

Key words: Nitrogen atom, functional group, C_sp3-H, transition metal

引用此文

张腾飞, 常喆, 陈春霞, 彭进松. 过渡金属催化氮原子α位C_sp3-H键官能团化反应研究进展[J]. 有机化学, doi: 10.6023/cjoc202404040.

Zhang Tengfei, Chang Zhe, Chen Chunxia, Peng Jinsong. Progress in functional group reaction of N-α-C_sp3-H bond catalyzed by transition metals[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202404040.

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