钌催化C(sp²)-H键的不对称官能化研究进展

doi:10.6023/cjoc202511025

摘要/Abstract

C-H键活化具有无需预官能团化、简洁、高效、绿色等优点,已成为一种合成有机化合物的常用策略。相比于钯、铑、铱等贵金属,钌催化剂具有催化剂成本低廉、合成容易、稳定好等优点,是最具发展前景的C-H键活化反应。钌催化的不对称C-H键官能团化研究为结构多样的手性化合物的合成提供新的选择。以不对称C(sp²)-H官能团化中调控产物手性的策略为分类依据,综述了近年来在钌催化C(sp²)-H键的不对称官能团化领域的进展,对反应的适用性,官能团兼容性,反应机理和局限性进行了总结,并对该领域所面临的问题、挑战进行了探讨,并对未来发展方向进行了展望。

关键词: 钌催化, 不对称催化, C-H键活化, C-H官能团化

C-H bond activation has emerged as a powerful and sustainable strategy for organic synthesis, as it avoids substrate pre-functionalization and offers simplicity, efficiency, and environmental friendliness. Compared to noble metals like palladium, rhodium, and iridium, ruthenium catalysts are more cost-effective, stable, and readily accessible, positioning them as highly promising for C-H activation. Ruthenium-catalyzed asymmetric C-H functionalization provides a versatile route to structurally diverse chiral molecules. This progress of asymmetric C(sp²)-H bond functionalization in recent years is dicussed, classified by asymmetric induced reaction strategies. The reaction scope, functional group tolerance, reaction mechanisms, and limitations of these methods were covered, and the future outlook and existing challenges are also provided.

Key words: Ruthenium catalysis, Asymmetric catalysis, C-H bond activation, C-H bond functionalization

引用此文

廖云, 唐丽娟, 宗映彤, 于道鸿. 钌催化C(sp²)-H键的不对称官能化研究进展[J]. 有机化学, doi: 10.6023/cjoc202511025.

Liao Yun, Tang Li-Juan, Zong Yingtong, Yu Daohong. Recent Progress in Ruthenium-Catalyzed Asymmetric Functionalization of C(sp²)-H Bonds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202511025.

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