水相中的自由基反应研究进展

doi:10.6023/cjoc202512028

有机化学 ›› 2026, Vol. 46 ›› Issue (4): 1496-1512.DOI: 10.6023/cjoc202512028 上一篇下一篇

综述与进展

水相中的自由基反应研究进展

王小曼^a^,^b, 王泽^a, 吴劼^a^,^c^,^d^,^*(), 胡燚^b^,^*(), 叶盛青^a^,^*()

^a 台州学院医药化工学院高等研究院高等研究院浙江台州 318000
^b 南京工业大学药学院药物绿色生物制造江苏省高校重点实验室药物绿色生物制造江苏省高校重点实验室江苏南京 211816
^c 中国科学院上海有机化学研究所金属有机化学国家重点实验室金属有机化学国家重点实验室上海 200032
^d 河南师范大学化学化工学院河南新乡 453007

收稿日期:2025-12-19 修回日期:2026-02-04 发布日期:2026-03-06
通讯作者: 吴劼, 胡燚, 叶盛青
基金资助:
国家自然科学基金(22271210)

Research Advances on Radical Reactions in Aqueous Phase

Xiaoman Wang^a^,^b, Ze Wang^a, Jie Wu^a^,^c^,^d^,^*(), Yi Hu^b^,^*(), Shengqing Ye^a^,^*()

^a School of Pharmaceutical and Chemical Engineering, Institute for Advanced Studies, Taizhou University, Taizhou, Zhejiang 318000
^b Jiangsu Provincial University Key Laboratory of Green Biomanufacturing for Pharmaceuticals, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, Jiangsu 211816
^c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
^d School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007

Received:2025-12-19 Revised:2026-02-04 Published:2026-03-06
Contact: Jie Wu, Yi Hu, Shengqing Ye
Supported by:
National Natural Science Foundation of China(22271210)

文章分享

摘要/Abstract

自由基在化学反应中具有高反应活性和独特的选择性等特点, 是构建复杂分子骨架的重要反应中间体. 然而, 传统的自由基反应严重依赖有毒、易挥发、易燃的有机溶剂, 而水作为一种无毒、不可燃、廉价易得且对环境友好的绿色溶剂, 发展以水为溶剂的自由基反应, 为突破传统自由基反应的局限性提供了很好的解决方案, 是当前绿色化学领域的一个前沿焦点. 本文主要总结了2020~2025年间以水为溶剂的自由基反应研究进展, 按照水相中的不同反应类型进行分类介绍, 主要有以下几类: (1) C—H/C—C键氧化反应, (2)偶联反应, (3)烯烃/炔烃自由基加成反应, (4)其他类型反应.

关键词: 水相反应, 自由基, 绿色化学

Free radicals always serve as significant reaction intermediates for constructing complex molecular frameworks, which characterized by high reactivity and special selectivity in organic synthesis. However, traditional radical reactions heavily rely on toxic, volatile and inflammable organic solvents. Meanwhile, taking advantage of the properties of water, such as non-toxic, non-flammable, cheap, accessible and eco-friendly, developing aqueous phase radical reactions offers an excellent solution to overcome these limitations. The above is the frontier focus in green chemistry currently. This review mainly summarizes the research advances on radical reactions in aqueous phase between 2020 and 2025, which are categorized into: (1) C—H/C—C bond oxidation reactions, (2) coupling reactions, (3) radical additions to alkenes/alkynes, and (4) other reactions.

Key words: aqueous reactions, radicals, green chemistry

引用此文

王小曼, 王泽, 吴劼, 胡燚, 叶盛青. 水相中的自由基反应研究进展[J]. 有机化学, 2026, 46(4): 1496-1512.

Xiaoman Wang, Ze Wang, Jie Wu, Yi Hu, Shengqing Ye. Research Advances on Radical Reactions in Aqueous Phase[J]. Chinese Journal of Organic Chemistry, 2026, 46(4): 1496-1512.

导出引用 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

分享此文

图/表 29

图式1. 水相中CeCl3催化的C—H键氧化反应

Scheme 1. C—H bond oxidation catalyzed by CeCl3 on water

图式2. 苄基C—H键氧化反应

Scheme 2. Benzyl C—H bond oxidation

图式3. 水相中CBr4诱导的苄基C—H键氧化反应

Scheme 3. Benzyl C—H bond oxidation mediated by CBr4 on water

图式4. 光催化下水相中的烯烃C=C氧化裂解反应

Scheme 4. Photocatalytic oxidative cleavage of alkene C=C on water

图式5. NaN3参与的水相中烯烃C=C的氧化裂解反应

Scheme 5. Oxidative cleavage of alkene C=C promoted by NaN3 in aqueous phase

图式6. 水相中硫代苯甲酸催化的烯烃光致氧化裂解反应

Scheme 6. Photocatalytic oxidative cleavage of alkenes catalyzed by thiobenzoic acid in aqueous phase

图式7. 水相中分子氧光诱导氧化反应

Scheme 7. Photoinduced oxidative strategy with molecular oxygen in aqueous phase

图式8. 水相中喹喔啉-2(1H)-酮的C3-二氟芳甲基化反应

Scheme 8. C3-Difluoroarylmethylation of quinoxalin-2(1H)- ones in aqueous phase

图式9. 水相中K2S2O8催化N-杂芳烃的酰胺烷基化反应

Scheme 9. K2S2O8-catalyzed amidoalkylation of N-heteroaromatics in aqueous phase

图式10. 水相中表面活性剂辅助下咪唑并[1,2-a]吡啶与N-氨基吡啶盐的光催化胺化反应

Scheme 10. Light-promoted amination of imidazo[1,2-a]pyridines with N-aminopyridinium salt by the assistance of surfactants on water

图式11. 水相中可见光诱导2-芳基-2H-吲唑的3-乙氧羰基甲基化反应

Scheme 11. Visible-light-induced direct 3-ethoxycarbonyl-methylation of 2-aryl-2H-indazoles in aqueous phase

图式12. 水相中可见光催化的过氧化苯甲酰参与的Minisci-型反应

Scheme 12. Photo-induced BPO-mediated Minisci-type reaction in aqueous phase

图式13. 水相中可见光促进尿嘧啶衍生物的C—H芳基化反应

Scheme 13. Visible-light-promoted C—H arylation of uracil derivatives in aqueous phase

图式14. 水相中可见光介导的N-酰化反应

Scheme 14. Visible-light-mediated N-acylation in aqueous phase

图式15. 水相中可见光诱导的三组分反应制备S-烷基二硫代氨基甲酸酯

Scheme 15. Three-component reaction access to S-alkyl dithiocarbamates under visible-light irradiation in aqueous phase

图式16. 水相中磺酰氟化物与芳基硼酸的偶联反应

Scheme 16. Cross-coupling of aryl boronic acids and sulfonyl fluorides on water

图式17. 可见光介导水中二酮类化合物与芳胺绿色合成叔醇

Scheme 17. Visible-light-mediated green synthesis of tertiary alcohols from dicarbonyl compounds and arylamines in aqueous phase

图式18. 基于水表面张力驱动的电极上聚集诱导的C—C键形成

Scheme 18. Aggregation-induced C—C bond formation on an electrode driven by the surface tension of water

图式19. 水相中乙烯基环丙烷的1,5-双官能化反应

Scheme 19. 1,5-Difunctionalization of vinylcyclopropane on water

图式20. 水相中可见光诱导表面活性剂促进的烯烃/炔烃的磺酰化反应

Scheme 20. Visible-light-induced surfactant-promoted sulfonylation of alkenes and alkynes on water

图式21. 水相中EDA络合物参与的三组分串联反应

Scheme 21. EDA-complex-mediated three-component tandem reaction in aqueous phase

图式22. 水相中可见光催化的EDA络合物参与的多组分反应

Scheme 22. Visible-light-activated multi-component reaction driven by the EDA complex in aqueous phase

图式23. 水相中烯烃与硫醇的反马氏规则官能化反应

Scheme 23. Anti-Markovnikov functionalization of alkenes with thiols in aqueous phase

图式24. 水相中自由基加成/环化反应合成3-酰甲基香豆素

Scheme 24. Synthesis of 3-acylmethylated coumarins via radical addition/cyclization reaction in aqueous phase

图式25. 对甲苯磺酰腙在水相中的卡宾光化学转化

Scheme 25. Photochemical transfers of carbenes from tosylhydrazones in aqueous phase

图式26. 水相中LMCT引发的脂肪羧酸的脱羧卤化反应

Scheme 26. LMCT-triggered decarboxylation halogenation of aliphatic carboxylic acids in aqueous phase

图式27. 水相中可见光催化的多组分反应合成萘硒唑-2-胺

Scheme 27. Synthesis of naphthoselenazol-2-amines through a visible-light-catalytic multi-component reaction in aqueous phase

图式28. 水相中可见光驱动的β-二羰基化合物的α-羟基化反应

Scheme 28. Visible-light-driven α-hydroxylation of β-dicarbonyl compounds in aqueous phase

图式29. 水相中聚集诱导的烯烃电化学硼化-二羟基化反应

Scheme 29. Aggregation-induced electrochemical boronation- dihydroxylation of alkenes on water

参考文献 54

[1]	Gomberg, M. J. Am. Chem. Soc. 1900, 22, 757.
[2]	Yan, M.; Lo, J. C.; Edwards, J. T.; Baran, P. S. J. Am. Chem. Soc. 2016, 138, 12692.
[3]	(a) Gao, S.-H.; Qiu, Y.-Y. Sci. China Chem. 2016, 59, 1093.
	(b) Xia, Q.; Dong, J.-Y.; Song, H.-J.; Wang, Q.-M. Chem.-Eur. J. 2019, 25, 2949.
	(c) Zhao, J.-P.; Ding, L.-J.; Wang, P.-C.; Liu, Y.; Huang, M.-J.; Zhou, X.-L.; Lu, M. Adv. Synth. Catal. 2020, 362, 5036.
	(d) Hou, L.-Z.; Zhou, Y.-Q.; Yu, H.; Zhan, T.-Y.; Cao, W.-D.; Feng, X.-M. J. Am. Chem. Soc. 2022, 144, 22140.
	(e) Ren, L.-Q.; Li, N.; Ke, J.; He, C. Org. Chem. Front. 2022, 9, 6400.
	(f) Hu, Z.-B.; Cheng, Z.-R.; Jiao, N. Chin. J. Chem. 2024, 42, 1157.
	(g) Zhang, J.-H.; Wang, J.-J.; Cheng, Q. Chin. J. Chem. 2024, 42, 1009.
	(h) Xiao, W.; Chen, J.-Q.;Wu. J. Chem. Soc. Rev. 2025, 54, 6832.
[4]	Nanda, B.; Sailu, M. S.; Priyaranjan, P. M.; Ranjan, P. K. P.; Nanda, B. B. Mater. Today Proc. 2021, 47, 1234.
[5]	Anastas, P. T.; Warner, J. C. Green Chemistry: Theory and Practice, New York, Oxford University Press, 1998.
[6]	Breslow, R. Acc. Chem. Res. 1991, 24, 159.
[7]	(a) Li, C.-J. Chem. Rev. 1993, 93, 2023.
	(b) Lindström, U. M. Chem. Rev. 2002, 102, 2751.
	(c) Breslow, R. Acc. Chem. Res. 2004, 37, 471.
	(d) Li, C.-J. Chem. Rev. 2005, 105, 3095.
	(e) Levin, E.; Ivry, E.; Diesendruck, C. E.; Lemcoff, N. G. Chem. Rev. 2015, 115, 4607.
	(f) Sun, K.; Lv, Q.-Y.; Chen, X.-L.; Qu, L.-B.; Yu, B. Green Chem. 2021, 23, 232.
	(g) Barata-Vallejo, S.; Yerien, D. E.; Postigo, A. ACS Sustainable Chem. Eng. 2021, 9, 10016.
	(h) Russo, C.; Brunelli, F.; Tron, G. C.; Giustiniano, M. J. Org. Chem. 2023, 88, 6284.
	(i) Yang, C.-R.; Wang, H.-H.; Xie, P. ChemSusChem 2025, 18, e202401915.
[8]	(a) Li, S.-L.; Zhu, B.; Lee, R.; Qiao, B.-K.; Jiang, Z.-Y. Org. Chem. Front. 2018, 5, 380.
	(b) Zhu, X.-J.; Liu, Y.; Liu, C.; Yang, H.-J.; Fu, H. Green Chem. 2020, 22, 4357.
	(c) Hosseini-Sarvari, M.; Dehghani, A. New J. Chem. 2020, 44, 16776.
	(d) Li, W.-J.; Li, S.; Luo, L.-H.; Ge, Y.-C.; Xu, J.-Q.; Zheng, X.-L.; Yuan, M.-L.; Li, R.-X.; Chen, H.; Fu, H.-Y. Green Chem. 2021, 23, 3649.
	(e) Zhao, J.-N.; Sun, H.-N.; Lu, Y.; Li, J.-N.; Yu, Z.-Y.; Zhu, H.-F.; Ma, C.-F.; Meng, Q.-W.; Peng, X.-J. Green Chem. 2022, 24, 8503.
[9]	Xie, P.; Xue, C.; Shi, S.-S.; Du, D.-D. ChemSusChem 2021, 14, 2689.
[10]	Bo, C.-B.; Bu, Q.-Q.; Liu, J.-C.; Dai, B.; Liu, N. ACS Sustainable Chem. Eng. 2022, 10, 1822.
[11]	(a) Hirashima, S.-I.; Nobuta, T.; Tada, N.; Miura, T.; Itoh, A. Org. Lett. 2010, 12, 3645.
	(b) Nobuta, T.; Fujiya, A.; Hirashima, S.-.; Tada, N.; Miura, T.; Itoh, A. Tetrahedron Lett. 2012, 53, 5306.
	(c) Tripathi, S.; Singh, S. N.; Yadav, L. D. S. RSC Adv. 2016, 6, 14547.
	(d) Yunusova, S. N.; Bolotin, D. S.; Vovk, M. A.; Tolstoy, P. M.; Kukushkin, V. Y. Eur. J. Org. Chem. 2020, 2020, 6763.
	(e) Kumar, S.; Shah, T. A.; Punniyamurthy, T. Org. Chem. Front. 2021, 8, 4288.
	(f) Tu, M.; Chen, B.-J.; Rukhsana; Cui, W.-Y.; Fu, W.-T.; Shen, C.-S.; Shen, Y.-M. New J. Chem. 2022, 46, 23276.
[12]	(a) Nishina, Y.; Ohtani, B.; Kikushima, K. Beilstein J. Org. Chem. 2013, 9, 1663.
	(b) Talukdar, R. Org. Biomol. Chem. 2020, 18, 8294.
	(c) He, X.; Yao, X.-Y.; Cai, S.-F.; Li, H.-R.; He, L.-N. Chem. Commun. 2022, 58, 5845.
[13]	Bo, C.-B.; Li, M.; Chen, F.; Liu, J.-C.; Dai, B.; Liu, N. ChemSusChem 2024, 17, e202301015.
[14]	(a) Wang, A.-Z.; Jiang, H.-F. J. Org. Chem. 2010, 75, 2321.
	(b) Tang, Q.-H.; Wang, Y.-Y.; Zhang, J.; Qiao, R.; Xie, X.-P.; Wang, Y.; Yang, Y.-H. Appl. Organomet. Chem. 2016, 30, 435.
	(c) Amaya, T.; Fujimoto, H. Tetrahedron Lett. 2018, 59, 2657.
[15]	Xie, P.; Xue, C.; Luo, J.-F.; Shi, S.-S.; Du, D.-D. Green Chem. 2021, 23, 5936.
[16]	Zhang, Y.-L.; Yue, X.-G.; Liang, C.-F.; Zhao, J.-M.; Yu, W.-B.; Zhang, P.-F. Tetrahedron Lett. 2021, 80, 153321.
[17]	(a) Wang, D.-H.; Wang, F.; Chen, P.-H.; Lin, Z.-Y.; Liu, G.-S. Angew. Chem. Int. Ed. 2017, 56, 2054.
	(b) Hazra, S.; Kaur, G.; Handa, S. ACS Sustainable Chem. Eng. 2021, 9, 5513.
	(c) Shee, M.; Singh, N. D. P. Chem. Soc. Rev. 2022, 51, 2255.
[18]	Yue, X.-G.; Ouyang, Y.-N.; Zhu, J.-S.; Yue, J.-F.; Peng, J.-H.; Li, W.-M. Asian J. Org. Chem. 2023, 12, e202300124.
[19]	Li, W.-J.; Liu, C.-Y.; Liang, L.-L.; Zhang, J.; Miao, Y.-Q. Org. Chem. Front. 2024, 11, 5429.
[20]	Gu, J.-Y.; Yang, H.; Deng, J.-F.; Jiang, D.-B.; Lv, K.-Z.; Wang, T.; Yao, Q.-L. Org. Chem. Front. 2024, 11, 1910.
[21]	(a) Song, J. J.; Reeves, J. T.; Gallou, F.; Tan, Z.-L.; Yee, N. K.; Senanayake, C. H. Chem. Soc. Rev. 2007, 36, 1120.
	(b) Baraldi, P. G.; Tabrizi, M. A.; Gessi, S.; Borea, P. A. Chem. Rev. 2008, 108, 238.
	(c) Archna; Pathania, S.; Chawla, P. A. Bioorg. Chem. 2020, 101, 104026.
	(d) Feng, Y.-D.; Zhang, Z.-Y.; Fu, Q.; Yao, Q.-H.; Huang, J.-H.; Shen, H.-B.; Cui, X.-L. Chin. Chem. Lett. 2020, 31, 58.
	(e) Yang, H.-Y.; Wang, Y.-F.; Wang, Y.; Zhang, Z.-Y.; Ma, H.-L.; Yamauchi, Y.; Ling, K.-J.; Zhao, Y.; Cai, S.-Z.; An, Z.-F.; Huang, W. Adv. Mater. 2025, 37, e03550.
[22]	(a) Matcha, K.; Antonchick, A. P. Angew. Chem. Int. Ed. 2013, 52, 2082.
	(b) Garza-Sanchez, R. A.; Tlahuext-Aca, A.; Tavakoli, G.; Glorius, F. ACS Catal. 2017, 7, 4057.
	(c) Candish, L.; Freitag, M.; Gensch, T.; Glorius, F. Chem. Sci. 2017, 8, 3618.
	(d) Cheng, W.-M.; Shang, R.; Fu, Y. ACS Catal. 2017, 7, 907.
	(e) Galloway, J. D.; Mai, D. N.; Baxter, R. D. Org. Lett. 2017, 19, 5772.
[23]	(a) Ries, U. J.; Priepke, H. W. M.; Hauel, N. H.; Handschuh, S.; Mihm, G.; Stassen, J. M.; Wienen, W.; Nar, H. Bioorg. Med. Chem. Lett. 2003, 13, 2297.
	(b) Liu, R.; Huang, Z.-H.; Murray, M. G.; Guo, X.-Y.; Liu, G. J. Med. Chem. 2011, 54, 5747.
	(c) Hussain, S.; Parveen, S.; Hao, X.; Zhang, S.-Z.; Wang, W.; Qin, X.-Y.; Yang, Y.-C.; Chen, X.; Zhu, S.-J.; Zhu, C.-J.; Ma, B. Eur. J. Med. Chem. 2014, 80, 383.
	(d) Ke, Q.-M.; Yan, G.-M.; Yu, J.; Wu, X.-M. Org. Biomol. Chem. 2019, 17, 5863.
[24]	Gao, Y.-H.; Zhao, L.-L.; Xiang, T.-Y.; Li, P.-H.; Wang, L. RSC Adv. 2020, 10, 10559.
[25]	Hong, G.-F.; Yuan, J.-W.; Fu, J.-H.; Pan, G.-Y.; Wang, Z.-W.; Yang, L.-R.; Xiao, Y.-M.; Mao, P.; Zhang, X.-M. Org. Chem. Front. 2019, 6, 1173.
[26]	Zhou, J.-D.; Ren, Q.-L.; Xu, N.; Wang, C.-D.; Song, S.-J.; Chen, Z.; Li, J.-J. Green Chem. 2021, 23, 5753.
[27]	Yang, Z.-L.; Cao, K.; Peng, X.-Y.; Lin, L.; Fan, D.-C.; Li, J.-L.; Wang, J.-X.; Zhang, X.-B.; Jiang, H.-Z.; Li, J.-H. Chin. J. Chem. 2021, 39, 3347.
[28]	Ma, C.-H.; Zhao, L.; He, X.; Jiang, Y.-Q.; Yu, B. Org. Chem. Front. 2022, 9, 1445.
[29]	(a) Jin, J.; MacMillan, D. W. Angew. Chem. Int. Ed. 2015, 54, 1565.
	(b) Quattrini, M. C.; Fujii, S.; Yamada, K.; Fukuyama, T.; Ravelli, D.; Fagnoni, M.; Ryu, I. Chem. Commun. 2017, 53, 2335.
	(c) Xu, P.; Chen, P.-Y.; Xu, H.-C. Angew. Chem. Int. Ed. 2020, 59, 14275.
	(d) Huang, H.; Strater, Z. M.; Lambert, T. H. J. Am. Chem. Soc. 2020, 142, 1698.
	(e) Liu, Y.-C.; Shi, B.-Y.; Liu, Z.; Gao, R.-F.; Huang, C.-L.; Alhumade, H.; Wang, S.-C.; Qi, X.-T.; Lei, A.-W. J. Am. Chem. Soc. 2021, 143, 20863.
[30]	Yang, J.-F.; Liu, Y.-F.; Wei, L.-L.; Qiao, K.-K.; Zhao, Y.-Q.; Shi, L. J. Org. Chem. 2024, 89, 4249.
[31]	Liu, A.-D.; Wang, Z.-L.; Liu, L.; Cheng, L. J. Org. Chem. 2021, 86, 16434.
[32]	(a) Yi, H.; Zhang, G.-Y.; Wang, H.-M.; Huang, Z.-Y.; Wang, J. Chem. Rev. 2017, 117, 9016.
	(b) Xie, J.; Jin, H.-M.; Hashmi, A. S. K. Chem. Soc. Rev. 2017, 46, 5193.
	(c) Sun, J.-W.; He, J.-Y.; Massaro, L.; Cagan, D. A.; Tsien, J.; Wang, Y.; Attard, F. C.; Smith, J. E.; Lee, J. S.; Kawamata, Y.; Baran, P. S. Nature 2025, 642, 85.
[33]	Xu, Y.-W.; Xu, X.-Z.; Wu, B.; Gan, C.-L.; Lin, X.-Y.; Wang, J.; Ke, F. Asian J. Org. Chem. 2020, 9, 1032.
[34]	Li, X.-H.; Cui, W.-W.; Deng, Q.-R.; Song, X.-Y.; Lv, J.; Yang, D.-S. Green Chem. 2022, 24, 1302.
[35]	Zhen, J.-S.; Li, Y.-H.; Yuan, H.; Xu, X.-H.; Du, X.; Li, X.-Q.; Luo, Y. Org. Chem. Front. 2023, 10, 404.
[36]	Hui, X.; Zhang, D.; Wu, C.-Y.; Ma, Y.-F.; Zhou, H.-H.; Zhu, Y.-B. Green Chem. 2023, 25, 2274.
[37]	Li, M.-F.; Cheng, X. Nat. Commun. 2024, 15, 7540.
[38]	(a) Jiang, H.; Studer, A. Chem. Soc. Rev. 2020, 49, 1790.
	(b) Yang, H.-F.; Wang, Y.-R.; Wang, L.-C.; Wu, X.-F. EES Catal. 2024, 2, 1247.
	(c) Ma, B.; Zhao, Z.; Ma, M.; Zhang, R.; Yang, J.-Y. Org. Chem. Front. 2025, 12, 3636.
	(d) Gu, L.-J.; Xu, R.-Y.; Huan, W.-W.; Zhang, Y. Org. Biomol. Chem. 2025, 23, 7681.
[39]	Liu, J.-K.; Yao, H.; Li, X.-N.; Wu, H.-Y.; Lin, A.-J.; Yao, H.-Q.; Xu, J.-Y.; Xu, S.-T. Org. Chem. Front. 2020, 7, 1314.
[40]	Lin, L.; Yang, Z.-L.; Liu, J.-C.; Wang, J.-X.; Zheng, J.-L.; Li, J.-L.; Zhang, X.-B.; Liu, X.-W.; Jiang, H.-Z.; Li, J.-H. Green Chem. 2021, 23, 5467.
[41]	Sun, B.; Tang, X.-L.; Zhuang, X.-H.; Ling, L.; Huang, P.-Y.; Wang, J.-Y.; Jin, C. Adv. Synth. Catal. 2023, 365, 1020.
[42]	Wang, Z.-K.; Wang, L.-X.; Lin, H.; Qiu, B.; Ma, Y.-C.; Xiao, J.; An, X.-D. Green Chem. 2025, 27, 4565.
[43]	Renzi, P.; Rusconi, M.; Ghigo, G.; Deagostino, A. Adv. Synth. Catal. 2023, 365, 4623.
[44]	Zhu, B.-F.; Ponnam, D.; Li, M.-Z.; Li, G.-K.; Fan, R.-F.; Chen, J.-C.; Fan, B.-M. J. Org. Chem. 2025, 90, 7738.
[45]	Yan, K.-C.; He, H.; Li, J.-L.; Luo, Y.; Lai, R.-Z.; Guo, L.; Wu, Y. Chin. Chem. Lett. 2021, 32, 3984.
[46]	Xu, P.; Huang, P.-Y.; Jiang, Y.; Lv, C.; Li, P.-X.; Wang, J.-Y.; Sun, B.; Jin, C. Green Chem. 2023, 25, 8741.
[47]	(a) Duddeck, H.; Bradenahl, R.; Stefaniak, L.; Jazwinski, J.; Kamienski, B. Magn. Reson. Chem. 2001, 39, 709.
	(b) Liu, J.; Xu, S.-J.; Huang, C.; Shen, J.-T.; Yu, S.; Yu, Y.-Z.; Sun, Q.-Y.; Dai, Q.-Y. Bioorg. Med. Chem. Lett. 2022, 73, 128913.
[48]	Hasan, C.; Hunter, R. F. J. Chem. Soc. 1935, 1762.
[49]	Ji, H.-T.; Wang, K.-L.; Ouyang, W.-T.; Luo, Q.-X.; Li, H.-X.; He, W.-M. Green Chem. 2023, 25, 7983.
[50]	(a) Olack, G.; Morrison, H. J. Org. Chem. 1991, 56, 4969.
	(b) Guanti, G.; Banfi, L.; Powles, K.; Rasparini, M.; Scolastico, C.; Fossati, N. Tetrahedron: Asymmetry 2001, 12, 271.
	(c) Christoffers, J.; Werner, T.; Frey, W.; Baro, A. Chem. Eur. J. 2004, 10, 1042.
[51]	(a) Liang, Y.-F.; Jiao, N. Angew. Chem. Int. Ed. 2014, 53, 548.
	(b) Chaudhari, M. B.; Sutar, Y.; Malpathak, S.; Hazra, A.; Gnanaprakasam, B. Org. Lett. 2017, 19, 3628.
	(c) Wang, Y.-T.; Lu, R.; Yao, J.; Li, H.-R. Angew. Chem. Int. Ed. 2021, 60, 6631.
	(d) He, Y.-J.; Yin, H.; Wang, Y.-F.; Chu, M.-M.; Li, Y.-M. RSC Adv. 2023, 13, 7843.
[52]	Wang, Y.; Wang, Z.-J.; Luo, H.; Wang, G.-H.; Shi, Z.-D.; Ma, Y.-F.; Wu, J.-L.; Li, D.-J.; Yang, J.-H. Org. Chem. Front. 2024, 11, 5524.
[53]	(a) Sauer, G. S.; Lin, S. ACS Catal. 2018, 8, 5175.
	(b) Xiong, P.; Long, H.; Song, J.-S.; Wang, Y.-H.; Li, J.-F.; Xu, H.-C. J. Am. Chem. Soc. 2018, 140, 16387.
	(c) Zhang, W.; Lin, S. J. Am. Chem. Soc. 2020, 142, 20661.
	(d) Song, L.; Fu, N.-K.; Ernst, B. G.; Lee, W.-H.; Frederick, M. O.; DiStasio, R. A.; Lin, S. Nat. Chem. 2020, 12, 747.
	(e) Siu, J. C.; Fu, N.-K.; Lin, S. Acc. Chem. Res. 2020, 53, 547.
	(f) Wang, Y.-L.; Dana, S.; Long, H.; Xu, Y.; Li, Y.-J.; Kaplan-Eris, N.; Ackermann, L. Chem. Rev. 2023, 123, 11269.
[54]	Li, M.-F.; Pu, T.-F.; Cheng, X. Synthesis 2025, 57, 2063.

水相中的自由基反应研究进展

Research Advances on Radical Reactions in Aqueous Phase

RichHTML

PDF

可视化

摘要/Abstract

引用此文

分享此文

图/表 29

参考文献 54

相关文章 15

编辑推荐

相关统计

本文评价

[1]	侯馨怡, 史同同, 李泽江, 董庆昊, 孙凯, 王薪. 可见光诱导的磷酰化环化合成磷酰基取代的吲哚并二氮䓬[J]. 有机化学, 2026, 46(4): 1776-1787.
[2]	邹震雷, 李益凡, 陈晨, 陈王哲, 张为钢, 王毅. 关于亚磺酰基砌块法合成亚砜的研究进展[J]. 有机化学, 2026, 46(4): 1635-1658.
[3]	王齐翔, 陈圣希, 王静, 陈栋, 鲍晓光, 吴新鑫. 无金属参与的多烯选择性氯代反应[J]. 有机化学, 2026, 46(4): 1750-1762.
[4]	郑婧斐, 吕琪妍, 孙凯, 陈晓岚, 屈凌波, 王金泉, 於兵. 自由基介导的6-氮杂尿嘧啶官能团化研究进展[J]. 有机化学, 2026, 46(4): 1603-1620.
[5]	刘世峥, 窦明煜, 崔玉, 窦建民, 魏文廷. 自由基硒磺酰化研究进展[J]. 有机化学, 2026, 46(4): 1621-1634.
[6]	赵雨晴, 朱先进, 石凌宇, 魏鸣宇, 徐紫涵, 石永佳, 李旭锋, 杨道山. 环硫鎓盐开环官能化反应的研究进展[J]. 有机化学, 2026, 46(4): 1572-1602.
[7]	杨珊, 陈亚苏, 朱晨. 自由基介导的官能团迁移-环化构建含氮稠杂芳烃[J]. 有机化学, 2026, 46(4): 1739-1749.
[8]	陈嘉豪, 占贝贝, 张夏衡. 自由基介导的1,n-氮迁移反应研究进展[J]. 有机化学, 2026, 46(4): 1560-1571.
[9]	卢琳玉, 亓雨彤, 张庭珲, 金胜男, 曹中艳, 张洪伟. 自由基介导烯烃的1,2,n-三官能团化反应研究进展[J]. 有机化学, 2026, 46(4): 1540-1559.
[10]	唐玉青, 杨紫娴, 杨兵, 王毅, 杜炳南. 球磨条件下机械力驱动的自由基反应研究进展[J]. 有机化学, 2026, 46(4): 1111-1145.
[11]	董建洋, 薛东. 自由基途径的[1.1.1]螺桨烷官能化研究进展[J]. 有机化学, 2026, 46(4): 1464-1480.
[12]	缪宇辰, 杞航, 黄焕明. 可见光/铬协同催化的对映选择性转化反应研究进展[J]. 有机化学, 2026, 46(4): 1481-1495.
[13]	李明强, 周磊. Dowd-Beckwith反应: 从卤原子转移到现代引发策略[J]. 有机化学, 2026, 46(4): 1428-1439.
[14]	王钰涓, 朱峰, 杨波. 完全未保护糖的自由基糖基化反应[J]. 有机化学, 2026, 46(4): 1529-1539.
[15]	于琛, 李宁, 薛琦, 李杨, 汪苇航, 李金恒. 自由基介导双C—H键转化的烯烃官能团化反应研究进展[J]. 有机化学, 2026, 46(4): 1440-1463.