Two novel chrial bisaminoalcohols,1,3-bis-[(2′S)-(diphenylhydroxymethyl)pyrrolidin-1-yl]-2-pro~pa~none (3) and 1,3-bis-[(2′S)-(diphenylhydroxymethyl)pyrrolidin-1-yl]-2-propanol (4), were prepared using the 1,3-dibromo-2-propanone and (2′S)-(diphenylhydroxymethyl)pyrrolidine as the starting materials. The yields were 39% and 35%, respectively. The asymmetricdirect aldol reactions of unmodified ketones and aldehydes were achieved with the ee up to 9% by using the bisaminoalcohol-diethylzinc as the catalyst.

Key words: chiral β-aminoalcohol, direct aldol reaction, catalyst