Gold(I)-Catalyzed Intermolecular Alkylation Reaction of  Indoles with Terminal Alkynes

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (03): 432-436. Previous Articles Next Articles

Original Articles

金催化的吲哚与末端炔烃的分子间烷基化反应

王翔^a,b; 赖媛媛^a,c ; 吴宏^a; 张建明^a ; 李永建^*,a

(a华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079)
(b凯里学院化学系凯里 556000)
(c国防科技大学航天与材料工程学院长沙 410073)

收稿日期:2008-08-05 修回日期:2008-11-10 发布日期:2009-03-20
通讯作者: 李永建

Gold(I)-Catalyzed Intermolecular Alkylation Reaction of Indoles with Terminal Alkynes

Wang, Xiang ^a,b; Lai, Yuanyuan ^a,c ; Wu, Hong ^a; Zhang, Jianming^a; Li, Yongjian^*,a

(a Key Laboratory of Pesticides and Chemical Biology, Ministry of Education,
College of Chemistry, Central China Normal University, Wuhan 430079)
(b Department of Chemistry, Kaili College, Kaili 556000)
(c Department of Material Engineering and Applied Chemistry, National University of
Defense Technology, Changsha 410073)

Received:2008-08-05 Revised:2008-11-10 Published:2009-03-20
Contact: Li, Yongjian

Abstract

An intermolecular Friedel-Crafts alkylation reaction of substituted indoles with terminal alkynes has been carried out in the presence of gold(I) complex as the catalyst. The β-bis(indol-3-yl)alkane derivatives were synthesized for the first time and identified by 1H NMR, 13C NMR, MS techniques and elemental analysis. A possible reaction mechanism has been suggested.

Key words: gold catalyst, β-bis(indol-3-yl)alkane, indole, alkyne, Friedel-Crafts alkylation

Cite this article

Wang, Xiang ^a,b; Lai, Yuanyuan ^a,c ; Wu, Hong ^a; Zhang, Jianming^a; Li, Yongjian^*,a. Gold(I)-Catalyzed Intermolecular Alkylation Reaction of Indoles with Terminal Alkynes[J]. Chin. J. Org. Chem., 2009, 29(03): 432-436.

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金催化的吲哚与末端炔烃的分子间烷基化反应

Gold(I)-Catalyzed Intermolecular Alkylation Reaction of Indoles with Terminal Alkynes

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