CuCN-TsOH Catalyzed Synthesis of 2-Aryl-4,5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor

doi:10.6023/cjoc201604038

Abstract

2-Imidazolines were synthesized via CuCN^-TsOH catalyzed cyclization of nitriles with ethylenediamine in a continuous-flow microreactor. The CuCN^-TsOH dissolves in ethylenediamine homogeneously and is a suitable catalyst for the continuous reactions. Under the flow condition, the 2-imidazolines were obtained with high yields in 5 min for most substrates. The "in-tube retention time gradient" (IT-RTG) is achieved in the continuous-flow microreactor, and it is applied in monitoring the reaction progress.

Key words: continuous-flow microreactor, 2-imidazoline, catalysis, cuprous cyanide, nitrile, cyclization

Cite this article

Zhou Junjie, Tang Zhike, Zhang Chao, Wang Dongtian, Zhang Kai, Sun Hongbin. CuCN^-TsOH Catalyzed Synthesis of 2-Aryl-4,5-dihydro-1H-imidazoline in a Continuous-Flow Microreactor[J]. Chin. J. Org. Chem., 2016, 36(11): 2662-2669.

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连续流微反应器中CuCN^-TsOH催化合成2-芳基-4,5-二氢-1H-咪唑啉