Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 1124-1130.DOI: 10.6023/cjoc202008047 Previous Articles     Next Articles

ARTICLES

2-[3-氰基呋喃-2(5H)-亚基]丙二腈衍生物的合成及其对Pd2+的识别

钟克利a, 周璐璐a, 陈琳a, 汤立军a,*(), 高雪b, 刘秀英b, 庞秀秀c, 燕小梅c,*()   

  1. a 渤海大学化学与材料工程学院 辽宁锦州 121013
    b 渤海大学食品科学与工程学院 生鲜农产品贮藏加工及安全控制技术国家地合工程研究中心 辽宁锦州 121013
    c 大连医科大学检验医学院 辽宁大连 116044
  • 收稿日期:2020-08-25 修回日期:2020-11-03 发布日期:2020-11-12
  • 通讯作者: 汤立军, 燕小梅
  • 基金资助:
    国家自然科学基金(21878023); 国家自然科学基金(U1608222); 辽宁省自然科学基金指导计划(2020-MS-289); 辽宁省自然科学基金指导计划(20180551195); 辽宁特聘教授支持计划资助项目.

Synthesis of 2-(3-Cyanofuran-2(5H)-ylidene)malononitrile Derivative and Its Recognition for Pd2+

Keli Zhonga, Lulu Zhoua, Lin Chena, Lijun Tanga,*(), Xue Gaob, Xiuying Liub, Xiuxiu Pangc, Xiaomei Yanc,*()   

  1. a College of Chemistry and Material Engineering, Bohai University, Jinzhou, Liaoning 121013
    b National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, College of Food Science and Technology, Bohai University, Jinzhou, Liaoning 121013
    c College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning 116044
  • Received:2020-08-25 Revised:2020-11-03 Published:2020-11-12
  • Contact: Lijun Tang, Xiaomei Yan
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21878023); National Natural Science Foundation of China(U1608222); Natural Science Foundation of Liaoning Province(2020-MS-289); Natural Science Foundation of Liaoning Province(20180551195); Program for Distinguished Professor of Liaoning Province.

2-(3-Cyano-furan-2(5H)-methylene)malononitrile derivative (TCF-Pyn) was synthesized by a two-step reaction. Compound TCF-Pyn could recognize Pd2+ with a high selectivity, “OFF-ON” fluorescent response and the near-infrared emission (653 nm) in MeCN/PBS ( VV=2∶8, PBS 2×10–2 mol/L, pH=7.4) solution. The probe possesses a good anti- interference capability, a wide pH range (3~8) and a low detection limit (6.92 μmol/L). The application research showed that TCF-Pyn could detect Pd2+ in real water samples and fluorescent image Pd2+in living cells.

Key words: fluorescent probe, near-infrared emission, recognition, Pd2+, cell imaging