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综述与进展

基于亚胺瞬态导向策略的过渡金属催化的碳氢键活化

吴勇杰, 史炳锋   

  1. 浙江大学 化学系 杭州 310027
  • 收稿日期:2020-03-25 修回日期:2020-04-30 出版日期:2030-01-01 发布日期:2020-05-11
  • 通讯作者: 史炳锋 E-mail:bfshi@zju.edu.cn
  • 基金资助:
    项目受国家自然科学基金(21925109,21772170),浙江省万人计划青年拔尖(ZJWR0108),中央高校基本科研业务费(2018XZZX001-02),浙江省自然科学金(LR17B020001)资助

Transition Metal-Catalyzed C-H Activation via Imine-Based Transient Directing Group Strategy

Wu Yong-Jie, Shi Bing-Feng   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China
  • Received:2020-03-25 Revised:2020-04-30 Online:2030-01-01 Published:2020-05-11
  • Supported by:
    Project supported by the the National Natural Science Foundation of China (21925109, 21772170), Outstanding Young Talents of Zhejiang Province High-level Personnel of Special Support (ZJWR0108), the Fundamental Research Funds for the Central Universities (2018XZZX001-02), Zhejiang Provincial NSFC (LR17B020001).

在过去几十年,过渡金属催化的碳氢键活化取得了巨大的发展,并给有机合成领域带来了革命性的改变.与传统的通过共价连接的导向基相比,基于瞬态导向策略的碳氢键活化,因为规避了传统导向基需要额外的步骤进行安装和脱除的不足,极大地提高了合成效率,拓宽了合成应用范围.本文综述了近年来基于亚胺瞬态导向策略的过渡金属催化的碳氢键活化的研究进展,着重探讨了各种瞬态导向基及其应用.全文按照底物类型和所活化碳氢键的类型进行分类,并对该领域目前存在的局限性和未来发展进行了总结和展望.

关键词: 瞬态导向策略, 过渡金属, 碳氢键活化, 亚胺, 导向基

In the past decades, transition metal-catalyzed C-H activation has experienced tremendous growth and revolutionized the field of organic synthesis. Several elegant strategies have been developed to promote reactivity and control precise site-selectivity. Among which, transient directing group strategy has been recognized to be an efficient and powerful approach for selective C-H functionalization. In contrast to traditional directing groups with covalent linkage, transient directing group strategy circumvents the covalent installation and removal of directing groups, which significantly improve the synthetic efficiency and broaden the range of synthetic applications. This review summarized recent advances in imine-based transition directing groups, providing an overview of recent achievements in this cutting-edge research field over the past few years. For clarity, this review was classified into two sections according to the types of functionality of the substrates. Emphasis is placed on the fully discussion of various transient directing groups and their applications. Finally, the limitations of previous works and perspectives on this cutting-edge area are also described.

Key words: transient directing group strategy, transition metal, C-H activation, imine, directing groups