有机化学 ›› 1997, Vol. 17 ›› Issue (6): 547-550. 上一篇    下一篇

研究论文

7,8-二氢-6,6-二甲基-7,8-环氧-6氢-吡喃[2,3-f]苯并-2,1,3-恶二唑的合成

孙宏斌;华维一;陈玲;彭司勋   

  1. 中国药科大学药物化学研究室
  • 发布日期:1997-12-25

Synthesis of 7,8-dihydro-6,6-dimethyl-7,8-epoxy-6H-pyrano[2,3-f] benzo-2,1,3-oxadiazole

SUN HONGBIN;HUA WEIYI;CHEN LING;PENG SIXUN   

  • Published:1997-12-25

本文给出了一条较好的制备7,8-二氢-6,6-二甲基-7,8-环氧-6氢-吡喃[2,3-f]苯并-2,1,3-恶二唑的合成路线,即由对乙酰氨基苯酚经酯化、Fries重排、环合、还原、脱水、硝化、脱酰基、氧化、脱氧和催化环氧化等反应制得标题化合物,其结构经元素分析和光谱数据确证。

关键词: 硝基化, 还原反应, 乙酰氨基, 降压药, 费赖斯重排, 脱水反应, 有机合成, 环氧化反应, 酯化, 苯并吡喃 P

A practical procedure for the synthesis of 7,8-dihydro-6,6-dimethyl- 7,8-epoxy-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole, the key intermediate for the synthesis of a series of potassium channel openers related to NIP-121 (compound 1), has been developed which involved the catalytic epoxidation of benzfurazan derivative 12.

Key words: NITRATION, ACETAMIDO GROUP, REDUCTION REACTION, EPOXIDATION REACTION, FRIES REARRANGEMENT, ORGANIC SYNTHESIS, DEHYDRATION REACTION, ESTERIFICATION, BENZOPYRAN P, ANTIHYPERTENSIVE AGENTS

中图分类号: