关键词: 导向有机合成, 钯化, 钯化合物, 铜化合物, 环化, 碳化, 偶联, 锂化反应, 区域选择性, 联烯, 有机合成, 导向剂, 元素有机化学

This papaer summarizes Dr. Shengming Ma's major research achievement since 1997, which includes: (1) the cyclizatino reaction of functionalized allenes, such as 1, 2-allenyl carboxylic acids, amides, ketones, 2, 3-allenyl alcohols or 2-(2', 3'-allenyl) malonates providing new entries for the efficient synthesis of heterocycles and carbocycles; (2) monolithiation of 1-aryl-1-alkynes under the catalysis of 1.5 mol% HgCl2, and the subsequent tunable regioselective coupling reaction with organic halides; (3) bicyclic carbopalladation of 1, 1-dibromo-1-alkenes providing a new and efficient entry for the construction of fused bicycles.

Key words: PALLADIUM COMPOUNDS, COPPER COMPOUNDS, CYCLIZATION, CARBONIZATION, COUPLED, LITHIATION, REGIOSELECTIVITY, ORGANIC SYNTHESIS, DIRECTING AGENT, ELEMENTARY ORGANIC CHEMISTRY