有机化学 ›› 1986, Vol. 6 ›› Issue (4): 281-285. 上一篇    下一篇

研究论文

5β,3α-羟基-7-羰基-胆烷酸的还原反应

庄治平;陈英;周维善   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1986-08-25

Reduction of 5\b\,3\a\-hydroxy-7-keto-cholic acid

ZHUANG ZHIPING;CHEN YING;ZHOU WEISHAN   

  • Published:1986-08-25

鹅去氧胆酸(2)经氧化得到5β,3α-羟基-7-羰基-胆烷酸(3),3的还原反应是制备熊去氧胆酸(1)的关键步骤.本文报道用碱金属和几种金属硼氢化物对3进行还原的结果.同时对两类不同还原剂的反应机理作了讨论.

关键词: 胆烷类, 反应机理, 脱氧胆酸, 羰基化合物, 还原反应, 胆酸, 熊胆

Reduction of the title compound (I) with hydride reducing agents gave mainly 7a-hydroxy derivative, whereas reduction with Li or Na gave mainly 7b-hydroxy derivative The reaction mechanism is discussed.

Key words: CHOLANES, REACTION MECHANISM, DEOXYCHOLIC ACID, CARBONYL COMPOUNDS, REDUCTION REACTION, BILE ACID, FEL URSI

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