有机化学 ›› 1998, Vol. 18 ›› Issue (1): 29-36. 上一篇    下一篇

研究论文

Microcellobospotia grisea中具有强抗肿瘤活性多糖重复单元中心片断的合成

于建新;刘方明;孙万赋;刘育亭;董颍;蔡孟深   

  1. 新疆大学化学系;北京医科大学药学院
  • 发布日期:1998-02-25

Syntheses of disaccharides corresponding to the repeat unit of the polysaccharide with antitumor effects from Microcellobospotia grisea

YU JIANXIN;LIU FANGMING;SUN WANFU;LIU YUTING;DONG YING;CAI MENGSHEN   

  • Published:1998-02-25

通过应用三氟乙酸酯法和Koenigs-Knorr方法,对Microcellobospotia grisea中具有强抗肿瘤活性多糖重复单元中心二糖片断进行了合成研究,并经元素分析,IR,^1H,^1^3C-NMR,^1H~^1H COSY及FAB-MS确证了合成得到的二糖片断10~13的结构。

关键词: 新疆大学科学基金, 多糖, 结构表征, 有机合成, 二糖, 抗肿瘤药

The syntheses of four blocked disaccharide fragments of the poly-saccharide with antitumor effects from Microcellobospotia grisea through the Koenigs-Knorr and trifluoroacetate methods were described, and their structures were confirmed by use of high resolution NMR and FAB-MS techniques.

Key words: ORGANIC SYNTHESIS, STRUCTURE CHARACTERISTICS, DISACCHARIDE, ANTITUMOR DRUGS, POLYSACCHARIDE

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