有机化学 ›› 2014, Vol. 34 ›› Issue (7): 1268-1276.DOI: 10.6023/cjoc201404010 上一篇    下一篇

研究专题

重氮化合物参与的不对称催化多组分反应

唐敏a,b, 邢栋a,b, 蔡茂强a,b, 胡文浩a,b   

  1. a 华东师范大学上海分子治疗与新药创制工程技术研究中心 上海 200062;
    b 华东师范大学化学系 上海 200062
  • 收稿日期:2014-04-03 修回日期:2014-05-21 出版日期:2014-07-25 发布日期:2014-06-09
  • 通讯作者: 胡文浩 E-mail:whu@chem.ecnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21125209,21332003)、科技部杰出青年基金(No.2011CB808600)和上海市科委重点基础研究基金(No.12JC1403800)资助项目.

Diazo Compounds-Involved Catalytic Asymmetric Multicomponent Reactions

Tang Mina,b, Xing Donga,b, Cai Maoqianga,b, Hu Wenhaoa,b   

  1. a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;
    b Department of Chemistry, East China Normal University, Shanghai 200062
  • Received:2014-04-03 Revised:2014-05-21 Online:2014-07-25 Published:2014-06-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21125209, 21332003), the Ministry of Science and Technology of China (No. 2011CB808600) and the Science and Technology Commission of Shanghai Municipality (No. 12JC1403800).

综述了近年来我们研究小组在重氮化合物参与的不对称催化多组分反应方面的研究进展. 基于对重氮化合物经由金属卡宾而生成的羟基叶立德、氨基叶立德或活泼离子对中间体的亲电捕捉,以及不同模式的协同催化策略,发展了不同类型的不对称催化多组分反应,实现了多种高效构建多官能团手性化合物的合成策略.

关键词: 重氮化合物, 金属卡宾, 不对称催化, 多组分反应, 协同催化

This accounts covers the recent advances in diazo compounds-involved catalytic asymmetric multicomponent reactions developed by our research group. Based on the electrophilic trapping of active oxonium ylides, ammonium ylides or zwitterionic intermediates that generated from diazo compounds via metal carbenes, an array of catalytic asymmetric multicomponent reactions have been developed. Cooperative catalytic strategies have been applied to control enantioselectivity of the reactions. These transformations offer efficient and powerful strategies for the synthesis of polyfunctional chiral molecules

Key words: diazo compound, metal carbene, catalytic asymmetric, multicomponent reaction, cooperative catalysis