有机化学 ›› 2014, Vol. 34 ›› Issue (10): 1958-1965.DOI: 10.6023/cjoc201405006 上一篇    下一篇

综述与进展

自由基加成/关环反应合成1,3-二氢吲哚-2-酮的研究进展

买文鹏, 王继涛, 杨亮茹, 袁金伟, 毛璞, 肖咏梅, 屈凌波   

  1. 河南工业大学化学化工学院 郑州 450001
  • 收稿日期:2014-05-06 修回日期:2014-05-26 出版日期:2014-10-25 发布日期:2014-06-23
  • 通讯作者: 买文鹏, 肖咏梅 E-mail:maiwp@yahoo.com;wpmai@aliyun.com
  • 基金资助:

    国家自然科学基金(Nos. 21302042,21172055)和郑州市创新团队(No. 131PCXTD605)资助项目.

Progress in Synthesis of Oxindoles by Radical Addition-Cyclization

Mai Wenpeng, Wang Jitao, Yang Liangru, Yuan Jinwei, Mao Pu, Xiao Yongmei, Qu Lingbo   

  1. School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001
  • Received:2014-05-06 Revised:2014-05-26 Online:2014-10-25 Published:2014-06-23
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21302042 and 21172055) & the Program for Innovative Research Team from Zhengzhou City (No. 131PCXTD605).

近两年来,关于自由基加成/关环反应合成1,3-二氢吲哚-2-酮的报道屡见不鲜. 它们大多以N-芳基取代的丙烯酰胺类化合物为底物,在各种不同的金属、无金属和光的催化作用下,与不同的自由基反应,可以一步生成3,3-二取代的吲哚-2-酮衍生物. 该类方法现已成为合成含氮五元杂环的一个重要手段,用来合成1,3-二氢吲哚-2-酮及其衍生物. 目前对自由基加成/关环反应合成该类化合物的研究多集中在不同催化手段引发不同的自由基和反应机理上. 按催化剂类型的不同,对近年来自由基加成/关环反应合成吲哚-2-酮的研究进展进行了综述.

关键词: 过渡金属, 非金属, 光催化, 1,3-二氢吲哚-2-酮

In recent years, there are many reports about the synthesis of oxindoles by radical addition-cyclization. Most of these approaches are catalyzed by different transition metals, or under metal-free and photoredox catalysis conditions using N-arylacrylamides as main substrates. These methods have been a powerful strategy to obtain oxindoles in organic synthesis. At present, the studies on the synthesis of oxindoles by radical addition-cyclization are mainly focused on the types of radicals and the reaction mechanisms. This review will summarize the recent progress of the synthesis of oxindoles by radical addition-cyclization according to the different catalyst systems.

Key words: transition metal, metal-free, photoredox catalysis, oxindoles