有机化学 ›› 2015, Vol. 35 ›› Issue (2): 259-272.DOI: 10.6023/cjoc201409026 上一篇    下一篇

综述与进展

手性烯烃配体在不对称催化领域的最新进展

冯向青, 杜海峰   

  1. 中国科学院化学研究所 北京分子科学国家实验室 分子识别与功能院重点实验室 北京 100190
  • 收稿日期:2014-09-11 修回日期:2014-10-16 出版日期:2015-02-25 发布日期:2014-10-22
  • 通讯作者: 杜海峰 E-mail:haifengdu@iccas.ac.cn
  • 基金资助:

    国家自然科学基金(No. 21222207)资助项目.

Application of Chiral Olefin Ligands in Asymmetric Catalysis

Feng Xiangqing, Du Haifeng   

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
  • Received:2014-09-11 Revised:2014-10-16 Online:2015-02-25 Published:2014-10-22
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21222207).

手性烯烃配体是一类具有重要应用前景的新型配体, 自发展以来就引起化学家们的广泛关注. 手性烯烃配体在一些反应中表现出比传统氮、磷、氧配体更高的活性和选择性, 实现了一些使用其它类型配体不能实现的化学转化. 为了增强手性烯烃配体与金属的配位能力, 化学家们在其骨架上引入杂原子, 发展得到混合型的烯烃配体, 增加了配体的多样性, 对进一步拓展手性烯烃配体的类型和应用具有非常重要的意义. 目前关于手性烯烃配体已经有一些综述, 本综述将着重介绍最近几年来发展的手性开链双烯配体、手性膦烯烃配体和手性硫烯烃配体及其在过渡金属催化的不对称反应领域的应用.

关键词: 手性烯烃配体, 不对称催化, 手性双烯配体, 手性膦烯配体, 手性硫烯配体

As a novel class of potential ligands, chiral olefin ligands have attracted much attention. Chiral olefin ligands exhibit higher activity and selectivity than the traditional nitrogen, phosphine, oxide ligands in some reactions, and solved some problems that other ligands could not do. To enhance the coordination of the olefin ligands and the metal, heteroatoms were introduced to its backbone, several hybrid olefin ligands have been developed to increase the diversity of the ligands for further expanding the application of chiral olefin ligands. In this review, the recent advances in the development of chiral diene ligands, chiral phosphine olefin ligands and chiral sulfur olefin ligands, and their application in transition-metal catalyzed asymmetric reactions are reviewed.

Key words: chiral olefin ligand, asymmetric catalysis, chiral diene ligand, chiral P/alkene ligand, chiral S/alkene ligand