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综述与进展

Anislactone类倍半萜的合成研究进展

李健a,b, 何龙a, 周志强a, 甄艳霞a, 谢卫青a   

  1. a 西北农林科技大学化学与药学院 陕西省天然产物化学生物学重点实验室 杨陵 712100;
    b 西北农林科技大学植物保护学院 杨陵 712100
  • 收稿日期:2020-05-12 修回日期:2020-06-15 出版日期:2030-01-01 发布日期:2020-06-28
  • 通讯作者: 谢卫青 E-mail:xiewq@nwafu.edu.cn
  • 基金资助:
    国家自然科学基金面上项目基金(No. 21722206, 21672171)资助项目.

Advances in the Synthesis of Anislactone-type Sesquiterpenes

Jian Lia,b, Long Hea, Zhiqiang Zhoua, Yanxia Zhena, Weiqing Xiea   

  1. a College of Chemistry & Pharmacy, Northwest A&F University, Shanxi Key Laboratory of Natural Products Chemistry and Biology Yangling 712100;
    b College of Plant Protection, Northwest A&F University, Yangling, 712100
  • Received:2020-05-12 Revised:2020-06-15 Online:2030-01-01 Published:2020-06-28
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21722206, 21672171)

(-)-Merrilactone A-C及anislactones A-B属于anislactone类倍半萜,此类天然产物具有特征5-5二环碳环骨架、双γ-丁内酯结构单元,分子中有密集手性中心及较高的氧化态.此外,这类天然产物表现出良好的神经营养活性,特别是(-)-merrilactone A,低浓度下仍然表现出优异的活性,具有开发为治疗阿尔兹海默症等神经退行性疾病药物的潜力.此类天然产物复杂的笼状结构在合成中极具挑战性,加上其优异的生物活性,这类天然产物的合成研究备受化学工作者的关注. 本文总结了近年来该类天然产物的全合成研究进展.

关键词: anislactone, merrilactone, 倍半萜, 全合成

The anislactone type sesquiterpenoids, (-)-merrilactones A-C and anislactones A-B, contain [5-5] bicyclic carbocyclic skeleton, two γ-butyrolactone structural units, featuring congested stereocenters and a high oxidation level. This type of natural products shows potent neurotrophic activity. Particularly, (-)-merrilactone A exhibits excellent neurotrophic activity even at lower concentration with potential for treating neurodisease such as Elzheimer disease. Due to their complex caged structures and excellent biologic profiles, the synthesis of aislactone-type sesquiterpenoids has attracted considerable attention from synthetic communities. This article summarizes the recent advances in the synthesis of this type of sesquiterpenoids.

Key words: anislactone, merrilactone, sesquiterpenes, total synthesis