Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2499-2503.DOI: 10.6023/cjoc201604021 Previous Articles     Next Articles



刘子召, 徐凡   

  1. 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2016-04-11 修回日期:2016-05-11 发布日期:2016-06-02
  • 通讯作者: 徐凡,
  • 基金资助:


Synthesis of Chromans via Domino Reaction of Phenols with Prenyl Bromide Catalyzed by Zinc Chloride

Liu Zizhao, Xu Fan   

  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2016-04-11 Revised:2016-05-11 Published:2016-06-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21272168).

Chroman skeleton exists in many natural and synthetic biologically active materials. A highly efficient method for the synthesis of chromans via reaction of phenols with prenyl bromide catalyzed by zinc chloride is described, which provides a practical process to afford this type of biologically important compounds in good yields using commercially available and inexpensive catalyst under mild conditions.

Key words: chroman, zinc chloride, catalysis, prenyl bromide