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庞海亮, 吴冬, 阴国印   

  1. 武汉大学高等研究院 武汉 430072
  • 收稿日期:2020-06-12 修回日期:2020-08-28 出版日期:2030-01-01 发布日期:2020-09-16
  • 通讯作者: 阴国印
  • 基金资助:

Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene

Pang Hailiang, Wu Dong, Yin Guoyin   

  1. Institute for Advanced Studies, Wuhan University, Wuhan 430072
  • Received:2020-06-12 Revised:2020-08-28 Online:2030-01-01 Published:2020-09-16
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21702151, 21871211) and the Fundamental Research Funds for Central Universities (No. 2042019kf0208).

A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed. This reaction exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity. The excellent selectivity suggests the olefin does not dissocate from the palladium during chain-walking. The method allows for the synthesis of 1,3-diaryl-substituted cyclohexanes from the readily accessible materials.

Key words: palladium catalysis, metal migration, alkene, stereoselectivity