金属催化芳基硼酸与酮不对称1,2-加成反应研究进展

doi:10.6023/cjoc201305044

摘要/Abstract

许多具有生物活性的天然产物及药物均含有手性芳基叔醇结构单元，金属催化芳基硼酸与酮不对称1，2-加成反应是合成该类化合物的有效方法. 由于芳基硼酸具有官能团兼容性好、对水及空气稳定、低毒等优点，近来已经成为化学家研究的热点. 就近年来金属催化芳基硼酸与活泼酮如靛红、三氟甲基酮、α-酮酯及1，2-二酮和不活泼酮的不对称1，2-加成的研究进展做一详细综述.

关键词: 金属催化, 芳基硼酸, 酮, 不对称, 1,2-加成, 研究进展

A number of biologically active compounds and drugs contain the structural unit of chiral aryl-substituted tertiary alcohol. The catalytic asymmetric arylation of ketones is a powerful tool for the efficient construction of such compounds. Arylboron reagents have attracted considerable attention due to their availability, relative insensitivity to air and moisture, high functional group tolerance and generally low toxicity. Recent progress of the catalytic asymmetric arylation of highly activated ketones such as isatins, trifluoromethyl ketones, α-ketoesters, 1, 2-diketones and unactivated ketones is reviewed.

Key words: metal-catalyzed, arylboronic acid, ketone, asymmetric, 1,2-addition, progress

引用此文

罗人仕, 廖建华, 张剑. 金属催化芳基硼酸与酮不对称1,2-加成反应研究进展[J]. 有机化学, 2013, 33(11): 2298-2309.

Luo Renshi, Liao Jianhua, Zhang Jian. Progress in the Asymmetric Metal-Catalyzed 1,2-Addition Reactions of Arylboronic Acids with Ketones[J]. Chin. J. Org. Chem., 2013, 33(11): 2298-2309.

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