有机化学 ›› 2025, Vol. 45 ›› Issue (6): 2171-2180.DOI: 10.6023/cjoc202409040 上一篇    下一篇

研究论文

HCF2SO2Na: 一种作为胺的硫代甲酰化试剂的新应用

胡春洋, Yasir Mumtaz, Khan Jahangir, 王雷秉, 蒋绿齐*()   

  1. 南京理工大学化学与化工学院 南京 210094
  • 收稿日期:2024-09-27 修回日期:2024-12-05 发布日期:2025-01-03
  • 通讯作者: 蒋绿齐
  • 作者简介:

    共同第一作者.

  • 基金资助:
    国家自然科学基金(22108124)

HCF2SO2Na: a New Application as a Thioformylation Reagent for Amines

Chunyang Hu, Yasir Mumtaz, Khan Jahangir, Leibing Wang, Lvqi Jiang*()   

  1. School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094
  • Received:2024-09-27 Revised:2024-12-05 Published:2025-01-03
  • Contact: Lvqi Jiang
  • About author:

    The authors contributed equally to this work.

  • Supported by:
    National Natural Science Foundation of China(22108124)

发展了一种HCF2SO2Na作为硫代甲酰化试剂的新应用. 该试剂经Ph3P还原后, 能够与胺类化合物发生作用, 实现硫代甲酰胺化合物的高效合成. 该方法选择性好, 反应体系适用于各类伯胺与仲胺类底物, 有较强的实用性. 该反应能够成功实现的关键在于HCF2SO2Na还原条件下原位生成的硫代甲酰氟(HCSF). 这种方法为硫代甲酰胺的合成提供了一种新的策略.

关键词: 二氟甲基亚磺酸钠, 还原, 硫代甲酰化,

A new application of HCF2SO2Na as a thiocarbonylation reagent was developed. The reagent is capable of interacting with amine molecules after reduction by Ph3P to achieve efficient synthesis of thioformamide compounds. The method is highly selective, and the reaction system is suitable for all kinds of primary and secondary amine substrates. The key to the successful realization of this reaction lies in the in situ generation of thioformyl fluoride (HCSF) under the reduction conditions of HCF2SO2Na. This strategy provides a new solution for the synthesis of thioformamides, which will effectively promote the application of this kind of substances in the synthesis.

Key words: HCF2SO2Na, reductive, thioformylation, amine