有机化学 ›› 2025, Vol. 45 ›› Issue (1): 189-195.DOI: 10.6023/cjoc202410007 上一篇    下一篇

研究论文

醋酸烯醇酯与硫氰酸钠电化学条件下α-硫氰化反应

张金鹏a,*(), 钱宇亮b, 宁梦妍b, 蔡童钦b, 苏张竞瑶b, 于泉b, 荣良策b,*()   

  1. a 徐州医科大学公共卫生学院 江苏省生物数据挖掘与医疗健康转化工程研究中心 江苏徐州 221004
    b 江苏师范大学化学与材料科学学院 江苏徐州 221116
  • 收稿日期:2024-10-14 修回日期:2024-12-12 发布日期:2024-12-26
  • 基金资助:
    江苏省高校自然科学基础研究计划(18KJA150004); 大学生创新创业训练计划(202410320109Y); 江苏省高校品牌专业及徐州美晗生物科技有限公司资助项目

α-Thiocyanation of Enol Acetates and Sodium Thiocyanate under Electrochemical Conditions

Jinpeng Zhanga(), Yuliang Qianb, Mengyan Ningb, Tongqin Caib, Jingyao Su-Zhangb, Quan Yub, Liangce Rongb()   

  1. a Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu 221004
    b School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, Jiangsu 221116
  • Received:2024-10-14 Revised:2024-12-12 Published:2024-12-26
  • Contact: *E-mail: lcrong@jsnu.edu.cn; caipj@163.com
  • Supported by:
    Natural Science Foundation of the Jiangsu Higher Education Institutions of China(18KJA150004); Undergraduate Innovation and Entrepreneurship Training Program(202410320109Y); Brand Major of Universities in Jiangsu Province and Xuzhou Meihan Biotechnology Co., Ltd.

报道了在电化学条件下醋酸烯醇酯与硫氰酸钠发生硫氰化反应. 研究表明, 由不同类型酮衍生的醋酸烯醇酯都可以应用于本反应体系, 而硫氰酸钠则是优秀的硫氰基源试剂. 本研究还具有操作简单、反应条件温和及底物范围广等优点, 为获得α-硫氰基酮衍生物提供了有效的合成途径.

关键词: 电化学, 醋酸烯醇酯, α-硫氰基化, 硫氰酸钠

An efficient electrochemical α-thiocyanation of enol acetates and sodium thiocyanate was reported in this research. The results showed that enol acetates derived from different types of ketones could be well used in this reaction strategy, and sodium thiocyanate was an excellent thiocyanate source reagent. This approach has the advantages of simple operation, mild reaction conditions and wide range of substrates, which provides an effective process for obtaining α-thiocyanatoones derivatives.

Key words: electrochemistry, enol acetates, α-thiocyanation, sodium thiocyanate