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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (6): 683-685. 上一篇    下一篇

研究简报

用钐和四氯化钛体系一锅法合成咪唑烷衍生物

余明新*, 张永敏   

  1. 浙江大学化学系 杭州 310027
  • 收稿日期:2003-10-08 修回日期:2003-11-27 接受日期:2003-12-22 发布日期:2022-09-21
  • 通讯作者: *E-mail: mingxinyu@css.zju.edu.cn
  • 基金资助:
    国家自然科学基金(No. 29872010)资助项目.

One Pot Synthesis of Imidazolidine Derivatives by Sm/TiCl4

YU, Ming-Xin*, ZHANG, Yong-Min   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027
  • Received:2003-10-08 Revised:2003-11-27 Accepted:2003-12-22 Published:2022-09-21

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在四氢呋喃溶液中,用Sm/TiCl4体系还原亚胺合成了咪唑烷衍生物.发现当没有促进剂1,2-二溴乙烷时,咪唑烷衍生物的产率小于20%,加入1,2-二溴乙烷后,产率大大提高.产物的结构通过IR, 1H NMR和MS光谱确证.根据实验结果提出了一个可能的反应机理.

关键词: 金属钐, 四氯化钛, 亚胺, 咪唑烷衍生物

Certain imines lead to the formation of imidazolidinederivative in THF with Sm/TiCl4 system. It was found that products of reductive coupling could be obtained in below 20% yields without 1,2-dibromoethane, while products of reductive coupling in moderate yields when 1,2-dibromoethane was added.The structures of all products were confirmed by IR, 1H NMR and MS spectra. According to the results of the experiment, a possible mechanism was proposed.

Key words: samarium, titanium tetrachloride, imine, imidazolidine derivative