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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1619-1625. 上一篇    

学术动态

光学活性脯氨酸催化的不对称有机合成反应

魏晓芳   

  1. (华东理工大学化学与制药学院 上海 200237)
  • 收稿日期:2005-02-01 修回日期:2005-08-15 发布日期:2005-11-30
  • 通讯作者: 魏晓芳

Optically Active Proline-catalyzed Enantioselective Organic Reactions

WEI Xiao-Fang   

  1. (Chemical and Pharmaceutical Institute, East China University of Science and Technology, Shanghai 200237)
  • Received:2005-02-01 Revised:2005-08-15 Published:2005-11-30
  • Contact: WEI Xiao-Fang

PDF

3162

被引次数

36

总结了D-或L-脯氨酸作为光学活性有机分子催化剂催化的涉及C＝O, N＝N, C＝N或N＝O键不对称Aldol型反应和α,β-不饱和烯酮及硝基烯烃的不对称共轭加成反应.

关键词: 脯氨酸, 不对称催化, 1,4-加成, 1,2-加成

Optically active prolines, i.e., L-proline and D-proline, are efficient catalysts for enantioselective Aldol-type reactions of C＝O, N＝N, C＝N or O＝N bonds and enantioselective conjugate additions of α,β-unsaturated enones and 1-nitroalkenes to afford optically active organic molecules with polyfunctionality.

Key words: enantioselective catalysis, 1,2-addition, 1,4-addition, proline