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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (9): 1261-1269.    下一篇

综述与进展

末端炔与亚胺及衍生物的不对称加成反应研究进展

边庆花，钟江春，侯士聪*，王敏   

  1. (中国农业大学理学院 北京 100193)
  • 收稿日期:2009-07-18 修回日期:2009-12-10 发布日期:2010-02-23
  • 通讯作者: 侯士聪 E-mail:houshc@cau.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

Advances of Enantioselective Addition of Terminal Alkynes to Imines and Their Derivatives

BIAN Qing-Hua, ZHONG Jiang-Chun, HOU Shi-Cong, WANG Min   

  1. (College of Sciences, China Agricultural University, Beijing 100193)
  • Received:2009-07-18 Revised:2009-12-10 Published:2010-02-23
  • Contact: Hou Shi-Cong Hou E-mail:houshc@cau.edu.cn

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被引次数

1 | 2

总结了近年来关于末端炔与亚胺及衍生物的不对称加成反应的研究进展, 包括小分子均相催化体系与固载化的手性催化剂. 其中小分子均相催化体系主要有: Pybox-铜、手性二胺-铜、Quinap-铜、Pinap-铜、磺酰胺亚胺-铜、二肽类-镐、氨基醇-锌等. 另外,还讨论了末端炔、醛与胺的多组分反应的研究.

关键词: 炔化反应, 亚胺, 不对称, 多组分反应, 进展

Recent advances of enantioselective additions of terminal alkynes to imines are reviewed in this paper. The asymmetric catalysts involve the homogeneous and immobilized ones. The homogeneous ones comprise copper complexes of Pybox, bisamines, Quinap, Pinap and tosylated aminoimine, zirconium com-plexes of peptidic chiral ligands, zinc complexes of aminoalcohols and Binols etc. The three-component addition reactions of terminal alkynes, aldehydes and amines are also discussed.

Key words: alkynylation, imine, asymmetric, three-component reaction, progress