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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (9): 1325-1335. 上一篇    下一篇

综述与进展

二苯基脯氨醇及其衍生物对前手性酮的不对称催化还原研究进展

刘祥伟 李夏冰 李宝林*   

  1. (陕西师范大学化学与材料科学学院 教育部药用资源与天然药物化学重点实验室 西安 710062)
  • 收稿日期:2008-07-14 修回日期:2008-12-20 发布日期:2009-12-30
  • 通讯作者: 李宝林

Advances in Asymmetric Reduction of Prochiral Ketones Catalyzed by Diphenylprolinol and Its Derivatives

Liu, Xiangwei Li, Xiabing Li, Baolin*   

  1. (School of Chemistry and Materials Science, Key Laboratory of the Ministry of Education for Medicinal Resources and
    Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi’an 710062, China)
  • Received:2008-07-14 Revised:2008-12-20 Published:2009-12-30
  • Contact: Li, Baolin

PDF

2700

被引次数

6

对(S)-α,α-二苯基脯氨醇及其衍生物对前手性酮的不对称催化还原研究进行了综述, 表明它们具有催化还原产率高、对映选择性好的作用, 是一类性能优秀的不对称还原反应的有机小分子催化剂.

关键词: (S)-α,α-二苯基脯氨醇, 不对称催化, 不对称还原, 前手性酮

This article briefly reviews the application of (S)-α,α-diphenylprolinol and its derivatives in catalyzed asymmetric reduction of prochiral ketones. The high yields and enantiomeric excess values indicate that they are excellent catalysts in the asymmetric reduction of prochiral ketones.

Key words: asymmetric catalysis, prochiral ketones, asymmetric reduction, (S)-α,α-diphenylprolinol