SIOC English
有机化学
高级检索

有机化学 ›› 1993, Vol. 13 ›› Issue (3): 297-298. 上一篇    下一篇

研究论文

钯催化的乙炔烷氧化物的环化和交叉偶合反应

罗芬台;WANG REN-TZONG;INESSA SCHREUDR   

  1. 中央研究院化学研究所
  • 发布日期:1993-06-25

Palladium-catalyzed cyclization and cross-coupling reactions of acetylenic alkoxides

LUO FENTAI;WANG REN-TZONG;INESSA SCHREUDR   

  • Published:1993-06-25

钯催化的乙炔醇化物的环化已表明是合成各种杂环的有效方法,但钯催化的从炔醇立体选择性合成呋喃叉或吡喃叉化合物还未见开发,本文报道了钯催化的用各种有机卤化物使炔醇的环化和交叉偶合反应的新策略.

关键词: 交叉偶合反应, 金属催化剂, 炔烃 P, 呋喃 P, 环化, 钯, 吡喃 P, 醇

Pd(OAc)2 or PdCl2 catalyzed the cyclization and cross-coupling of acetylenic alkyl or aryl alkoxides [e.g., alkoxides derived from 2-HOC6H4CH2CYCH, HO(CH2)3CYCH (I)] with organic halides (e.g., PhI, 2-iodothiophene) to give a-alkylidene cyclic ethers. E.g., treating I in THF with BuLi, then with Pd(OAc)2/PPh3, followed by PhI, gave furan II stereoselectively.

Key words: FURAN P, ALKYNE P, CYCLIZATION, METAL CATALYST, PALLADIUM, ALCOHOL, PYRANE P

中图分类号: