有机化学 ›› 1996, Vol. 16 ›› Issue (6): 497-506. 上一篇    下一篇

研究论文

糖肽合成的新进展

杜宇国;孔繁祚   

  1. 中国科学院生态环境研究中心
  • 发布日期:1996-12-25

Recent development in the syntheses of glycopeptides

DU YUGUO;KONG FANZUO   

  • Published:1996-12-25

本文综述了近年来在糖肽合成方面的研究进展, 主要包括三氯乙酰亚胺酯法, 缩水内醚糖法, 酶合成法, 固相合成法及酶与固相结合法。分析了不同的离去基团和不同的保护基策略对糖肽合成的影响。

关键词: 缩水内醚糖, 糖肽, 离去基, 固相合成, 保护基, 有机合成

This paper presents a review on the recent development of the glycopeptide syntheses. Several methodologies were described including chemical synthesis (glycosyl trichloroacetimidates or anhydrosugars as glycosyl donors), enzymatic synthesis, solid-phase synthesis and enzymatic solid phase synthesis. The factors which affect the results of glycopeptide synthesis were analyzed.

Key words: SOLIDPHASE SYNTHESIS, ORGANIC SYNTHESIS, PROTECTIVE GROUP, GLYCOPEPTIDE

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