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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (01): 65-68. 上一篇    下一篇

研究论文

(S)-和(R)-盐酸氟西汀的不对称合成

程青芳1,2，许兴友*,1,2，刘玮炜1，杨绪杰2，姚泳3   

  1. (1淮海工学院化工系 连云港 222005)
    (2南京理工大学材料化学实验室 南京 210094)
    (3江苏正大天晴药业股份有限公司 连云港 222006 )
  • 收稿日期:2005-03-24 修回日期:2005-07-18 发布日期:2005-12-31
  • 通讯作者: 许兴友

Enantioselective Synthesis of S- and R-Fluoxetine Hydrochloride

CHENG Qing-Fang1,2,XU Xing-You*,1,2,LIU Wei-Wei1
YANG Xu-Jie2,YAO Yong3   

  1. (1 Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005)
    (2 Materials Chemistry Laboratory, Nanjing University of Science and Technol-ogy, Nanjing 210094)
    (3 Jiangsu Zhengda Tianqing Pharmaceutical Co., Ltd., Lianyungang 222006)
  • Received:2005-03-24 Revised:2005-07-18 Published:2005-12-31
  • Contact: XU Xing-You

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盐酸氟西汀是一种临床广泛使用的非三环类抗抑郁药, 本工作介绍了一种不对称合成(S)-和(R)-盐酸氟西汀的方法. 以自制的手性噁唑硼烷为催化剂, 将起始原料β-氯苯丙酮不对称催化氢化还原成(S)-或(R)-手性醇, 这一步的化学收率和光学收率都较高. 然后再经两步, (S)-和(R)-手性醇转化为(S)-和(R)-盐酸氟西汀. 整个工艺只需三步, 总收率为66.5%, 盐酸氟西汀对映体的ee值可达98.6%. 还考察了反应温度、溶剂、催化剂的量等因素对β-氯苯丙酮的不对称氢化还原的化学产率和光学收率的影响.

关键词: 盐酸氟西汀, 制剂, 不对称还原, 手性噁唑硼烷

The enantioselective synthesis of fluoxetine hydrochloride, a potent serotonin-uptake inhibitor, was described. The asymmetric reduction of 3-chloropropiophenone catalyzed by chiral oxazaborolidines enantioselectively gave S- or R-3-chloro-1-phenylpropanol (2) in good yield. In following two steps, alcohol 2 was converted into S- or R-fluoxetine hydrochloride in 66.5% overall yield and 98.6% ee. Some factor effecting the yield and the enantioselectivity of asymmetric reduction of 3-chloropropiophenone was investigated.

Key words: fluoxetine hydrochloride, chiral oxazaborolidine, asymmetric reduction, inhibitor