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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (03): 286-296. 上一篇    下一篇

综述与进展

加兰他敏全合成研究进展

房雷1,2，苟少华*,1,2，张奕华3   

  1. (1东南大学化学化工学院药物研究中心 南京 210009)
    (2江苏省生物药物高技术研究重点实验室 连云港 222000)
    (3中国药科大学新药研究中心 南京 210009)
  • 收稿日期:2010-01-26 修回日期:2010-07-10 发布日期:2010-09-16
  • 通讯作者: 房雷 E-mail:fanglei24@googlemail.com

Progresses in Total Synthesis of Galantamine

Fang Lei1,2 Gou Shaohua*,1,2 Zhang Yihua3   

  1. (1 Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 210009)
    (2 Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Lianyungang 222000)
    (3 Center of Drug Dis-covery, China Pharmaceutical University, Nanjing 210009)
  • Received:2010-01-26 Revised:2010-07-10 Published:2010-09-16
  • Contact: Lei FANG E-mail:fanglei24@googlemail.com

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被引次数

11 | 4

加兰他敏为天然生物碱, 具有乙酰胆碱酯酶抑制及神经元烟碱受体构象调节双重活性, 临床应用非常广泛. 迄今, 研究人员已提出多种合成策略, 如分子内酚氧化缩合法、分子内Heck反应法等, 重点关注近几年加兰他敏全合成的研究进展, 并尝试对现有方法的发展演变以及各自特点进行综述.

关键词: 加兰他敏, 全合成, 研究进展

Galantamine, a natural alkaloid possessing AChE inhibitory and neuronal nicotinic receptor allosteric modulating effect, is widely used in clinic. Up to date, several different synthetic strategies have been developed for the total synthesis of galantamine, including the phenolic oxidative coupling reaction, the intramolecular Heck reaction, and so on. In this review, the recent progresses in the total synthesis of galantamine are reviewed. Furthermore, the evolution and the features of the existing strategies are also dis-cussed.

Key words: galantamine, total synthesis, progress