有机化学 ›› 2014, Vol. 34 ›› Issue (12): 2406-2411.DOI: 10.6023/cjoc201408030 上一篇    下一篇

综述与进展

过渡金属催化的不对称交叉脱氢偶联反应研究进展

张艳, 冯柏年   

  1. 江南大学药学院 无锡 214122
  • 收稿日期:2014-08-26 修回日期:2014-09-20 发布日期:2014-10-21
  • 通讯作者: 冯柏年 E-mail:fengbainian@jiangnan.edu.cn
  • 基金资助:

    国家自然科学基金(No.21302067)和江苏省自然科学基金(No.BK20130120)资助项目.

Asymmetric Catalytic Carbon-Carbon Coupling Reactions via Cross-Dehydrogenative Coupling Reactions

Zhang Yan, Feng Bainian   

  1. School of Pharmaceutical Science, Jiangnan University, Wuxi 214122
  • Received:2014-08-26 Revised:2014-09-20 Published:2014-10-21
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302067). and the Natural Science Foundation of Jiangsu Province (No. BK20130120).

C—C键的形成是药物合成过程中重要的研究内容之一. 交叉脱氢偶联直接利用不同反应底物中的C—H键在氧化条件下进行交叉偶联反应形成C—C键, 反应过程中避免了反应底物的预先官能化, 是构建新的碳-碳键简洁、高效的合成路径, 原子利用率高、环境友好, 具有重大的理论意义和应用价值. 综述了目前过渡金属催化的不对称交叉脱氢偶联反应, 重点阐述过渡金属与配体在反应的立体选择性中的应用.

关键词: 不对称催化, 交叉脱氢偶联, 碳氢活化

Asymmetric catalytic C—C coupling reactions via cross-dehydrogenative coupling are currently among the most attractive and powerful tools in synthetic organic chemistry. In the past few decades, a variety of catalytic asymmetric C—C coupling reactions via cross-dehydrogenative coupling have been reported. Compared with traditional asymmetric C—C bond formation reactions, cross-dehydrogenative coupling strategies have more advantages in terms of power and cost-effectiveness. In this review, the recent studies on enantioselective cross dehydrogenative-coupling are reviewed.

Key words: asymmetric catalysis, cross-dehydrogenative coupling, C—H activation