有机化学 ›› 2018, Vol. 38 ›› Issue (12): 3236-3241.DOI: 10.6023/cjoc201806026 上一篇    下一篇

研究论文

碘介导下通过氧化性C-O键形成合成异噁唑类化合物

侯姣, 张新婷, 于文全, 常俊标   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2018-06-16 修回日期:2018-08-02 发布日期:2018-08-23
  • 通讯作者: 于文全, 常俊标 E-mail:wenquan_yu@zzu.edu.cn;changjunbiao@zzu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.81773570,81330075)和郑州大学优秀青年人才研究基金(No.1521316004)资助项目.

I2-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles

Hou Jiao, Zhang Xinting, Yu Wenquan, Chang Junbiao   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2018-06-16 Revised:2018-08-02 Published:2018-08-23
  • Contact: 10.6023/cjoc201806026 E-mail:wenquan_yu@zzu.edu.cn;changjunbiao@zzu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81773570, 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004).

通过碘介导的氧化性C-O键形成反应由易得的αβ-不饱和肟合成了一系列单、双和三取代(芳基、烷基和/或烯基)的异噁唑类化合物.该合成方法具有不使用过渡金属、操作简单、反应条件温和、反应时间短,以及底物适用范围广等优点.

关键词: 异噁唑, 碘, α,β-不饱和肟, C-O键形成

A variety of mono-, di-, and tri-substituted (aryl, alkyl, and/or alkenyl) isoxazoles were synthesized from readily accessible α,β-unsaturated oximes via I2-mediated oxidative C-O bond formation. The features of this synthetic approach include no use of transition metals, simple operation, mild reaction conditions, short reaction time, and broad substrate scope.

Key words: isoxazole, iodine, α,β-unsaturated oxime, C-O bond formation