有机化学 ›› 2022, Vol. 42 ›› Issue (10): 3201-3212.DOI: 10.6023/cjoc202207046 上一篇    下一篇

所属专题: 不对称催化专辑

综述与进展

光催化去消旋化的研究进展

苏艺雯a,b, 邹有全a,b,*(), 肖文精c,*()   

  1. a 武汉大学药学院 武汉 430071
    b 武汉大学泰康生命医学中心 武汉 430071
    c 华中师范大学化学学院 武汉 430079
  • 收稿日期:2022-07-31 修回日期:2022-09-04 发布日期:2022-11-02
  • 通讯作者: 邹有全, 肖文精
  • 基金资助:
    武汉大学人才启动基金(691000002); 武汉大学人才启动基金(600460026); 国家自然科学基金(21820102003); 国家自然科学基金(91956201)

Recent Advances in Photocatalytic Deracemization

Yiwen Sua,b, Youquan Zoua,b(), Wenjing Xiaoc()   

  1. a School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071
    b TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071
    c College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2022-07-31 Revised:2022-09-04 Published:2022-11-02
  • Contact: Youquan Zou, Wenjing Xiao
  • Supported by:
    Start-up Funding from Wuhan University(691000002); Start-up Funding from Wuhan University(600460026); National Natural Science Foundation of China(21820102003); National Natural Science Foundation of China(91956201)

手性广泛存在于众多天然产物和药物分子中, 由于对映体之间具有不同甚至是相反的生理活性, 获得光学纯的手性化合物具有重要的研究意义. 去消旋化是获得单一对映体最直接、最有效和最原子经济的途径, 而新兴的光催化去消旋化由于其高效性更是备受瞩目. 综述了光催化去消旋化最新的研究进展, 并对该领域未来的研究前景进行了展望.

关键词: 去消旋化, 手性分子, 不对称合成, 光催化

Chirality is widely found in many natural products and drug molecules. It is of great significance to obtain optically pure chiral compounds because of the fact that different enantiomers have distinct or even opposite physiological activities. Deracemization is the most direct, efficient and atom-economic approach to obtain a single enantiomer, and the emerging photocatalytic deracemization attracts much attention because of its high efficiency. Herein, the recent advances in photocatalytic deracemization are summarized. The future research direction of this field is also prospected.

Key words: deracemization, chiral molecule, asymmetric synthesis, photocatalysis