小环化合物的不对称氢化研究进展

doi:10.6023/cjoc202603025

摘要/Abstract

由于手性三元与四元环状化合物在生物活性分子中作为关键结构单元广泛存在,且常作为重要中间体应用于药物研发等领域,因此其合成研究在有机化学领域占据重要地位。过渡金属催化的不对称氢化反应（包括加压氢化和转移氢化）凭借其卓越的催化效率、优异的对映选择性以及可规模化等显著优势,是构建手性小环化合物的理想方法,但面临诸多挑战,发展相对缓慢。本综述系统梳理了小环化合物不对称氢化领域的最新研究进展,重点聚焦于四元环底物（如β-内酰胺、环丁酮、环丁烯酮及环丁二烯酮）与三元环底物（包括偕二氟环丙烯基酯和偕二氟环丙烯基酮）的相关研究。

关键词: 不对称氢化, 三元环, 四元环, 对映选择性

Given that chiral three- and four-membered cyclic compounds are widely present as key structural units in bioactive molecules and are frequently employed as crucial intermediates in fields such as pharmaceutical development, their synthetic research holds a significant position in the realm of organic chemistry. Transition metal-catalyzed asymmetric hydrogenation reactions (including pressurized hydrogenation and transfer hydrogenation) are ideal methods for constructing chiral small ring compounds owing to their remarkable catalytic efficiency, excellent enantioselectivity, and scalability; however, various challenges exist and slow down the related development This review systematically summarizes the latest research progress in the field of asymmetric hydrogenation of small ring compounds, with a particular focus on studies related to four-membered ring substrates (such as β-lactams, cyclobutanones, cyclobutenones, and cyclobutadienones) and three-membered ring substrates (including gem-difluorocyclopropenyl esters and gem-difluorocyclopropenyl ketones).

Key words: asymmetric hydrogenation, three-membered rings, four-membered rings, enantioselectivity

引用此文

杨爽, 房新强. 小环化合物的不对称氢化研究进展[J]. 有机化学, doi: 10.6023/cjoc202603025.

Shuang Yang, Xinqiang Fang. Research Progress in Asymmetric Hydrogenation of Small Ring Compounds[J]. Chinese Journal of Organic Chemistry, doi: 10.6023/cjoc202603025.

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