Copper-Catalyzed the Synthesis of 3-Trifluoromethylchromone via Trifluoromethyl Radical Addition Tandem Cyclization Reaction of 2-Hydroxyphenyl Enaminones

doi:10.6023/cjoc202102007

Abstract

Chromones have shown strong drug activity in anti-tumor, antibacterial and anti-inflammatory aspects for their unique skeleton structure. Using Cu(OAc)₂ as catalyst, CF₃SO₂Na as trifluoromethyl radical source, tert-butanol peroxide (TBHP) as oxidant, 3-trifluoromethylchromone was synthesized by radical addition tandem cyclization reaction of 2-hydroxyphenyl enaminone under mild reaction conditions, and enaminone substrate has good functional tolerance.

Key words: radical addition, trifluoromethyl, enaminone, chromones

Cite this article

Keying Du, Zhanming Zhang, Weijian Sheng. Copper-Catalyzed the Synthesis of 3-Trifluoromethylchromone via Trifluoromethyl Radical Addition Tandem Cyclization Reaction of 2-Hydroxyphenyl Enaminones[J]. Chinese Journal of Organic Chemistry, 2021, 41(8): 3242-3248.

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