有机化学 ›› 2021, Vol. 41 ›› Issue (7): 2707-2714.DOI: 10.6023/cjoc202103029 上一篇    下一篇

研究论文

铁催化1,3-共轭烯烃的Heck型脱羧烷基化反应

王凯凯a, 陈绍维b, 李亚军b, 李达谅a,*(), 鲍红丽b,*()   

  1. a 福建师范大学南方生物医学研究中心&化学与材料学院 福州 350007
    b 中国科学院福建物质结构研究所 煤制乙二醇重点实验室 福州 350002
  • 收稿日期:2021-03-18 修回日期:2021-04-15 发布日期:2021-04-29
  • 通讯作者: 李达谅, 鲍红丽
  • 基金资助:
    国家自然科学基金(21871258); 国家自然科学基金(21922112); 国家自然科学基金(22001251); 福建师范大学校创新团队(IRTL1703)

Iron-Catalyzed Decarboxylative Heck-Type Alkylation of Conjugate 1,3-Dienes

Kaikai Wanga, Shaowei Chenb, Yajun Lib, Daliang Lia(), Hongli Baob()   

  1. a Biomedical Research Center of South China & College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007
    b Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002
  • Received:2021-03-18 Revised:2021-04-15 Published:2021-04-29
  • Contact: Daliang Li, Hongli Bao
  • Supported by:
    National Natural Science Foundation of China(21871258); National Natural Science Foundation of China(21922112); National Natural Science Foundation of China(22001251); Innovative Research Teams Program of Fujian Normal University(IRTL1703)

报道了铁催化的烷基过氧酰或者叔丁基过氧酯对1,3-共轭烯烃的Heck型脱羧烷基化反应. 这个方法提供了一个有效的对1,3-共轭烯烃进行Heck型烷基化的途径, 不但收率高, 而且有些情况下具有很高的区位选择性. 此方法也可以用来对生物活性分子进行后期Heck型烷基化修饰.

关键词: 铁催化, 1,3-共轭烯烃, Heck型烷基化, 脱羧反应, 过氧酯, 过氧酰

An iron-catalyzed decarboxylative Heck-type alkylation of conjugate 1,3-dienes with alkyl diacyl peroxides andt-butyl peresters is reported. This method offers an efficient approach to alkylation of 1,3-dienes with good yields, and in some cases with high selectivities. Late-stage alkylation of bioactive compounds was also found to be effective.

Key words: iron catalysis, 1,3-dienes, Heck-type alkylation, decarboxylation, peresters, diacyl peroxides