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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1508-1529. 上一篇    下一篇

综述与进展

Ni催化的碳(sp2)-碳和碳(sp2)-杂交叉偶联反应

李哲，傅尧，刘磊，郭庆祥*   

  1. (中国科学技术大学化学系 合肥 230026)
  • 收稿日期:2004-05-10 修回日期:2005-04-20 发布日期:2005-11-30
  • 通讯作者: 郭庆祥

Ni-catalyzed C(sp2)-carbon and C(sp2)-heteroatom Cross-coupling Reactions

LI Zhe, FU Yao, LIU Lei, GUO Qing-Xiang*   

  1. (Department of Chemistry, University of Science and Technology of China, Hefei 230026)
  • Received:2004-05-10 Revised:2005-04-20 Published:2005-11-30
  • Contact: GUO Qing-Xiang

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综述了Ni催化的碳(sp2)-碳和碳(sp2)-杂交叉偶联反应. 主要反应类型有: Heck反应、Sonogashira反应、Kumada-Corriu反应、Negishi反应、Stille反应、Suzuki反应、Ullmann反应、C—N偶联反应、C—O偶联反应、C—P偶联反应和C—S偶联反应. 详细地介绍了各个反应的底物要求、反应条件、反应选择性和产率. 最后, 我们对Ni催化的反应机理研究也作了总结.

关键词: 镍, 交叉偶联, 催化反应, 反应机理

Nickel-catalyzed C—C and C-heteroatom cross-coupling reactions are reviewed. The reactions include Heck reaction, Sonogashira reaction, Kumada-Corriu reaction, Negishi reaction, Stille reaction, Suzuki reaction, Ullmann reaction, C—N coupling, C—O coupling, C—P coupling, and C—S coupling. The substrates, reaction conditions, selectivities and yields of these reactions are described. The mechanistic studies on Ni-catalyzed reactions were also surveyed.

Key words: cross-coupling, catalytic reaction, Ni, reaction mechanism