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有机化学
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有机化学 ›› 2005, Vol. 25 ›› Issue (12): 1591-1593. 上一篇    下一篇

研究简报

二氧化碳促进的醛和酮等羰基化合物烯丙基化反应研究

李金恒*，廖华，梁云，尹笃林   

  1. (湖南师范大学化学化工学院 化学生物学与中药分析重点实验室 长沙 410081)
  • 收稿日期:2004-08-19 修回日期:2005-06-16 发布日期:2005-11-30
  • 通讯作者: 李金恒

Carbon Dioxide Promoted Allylation of Aldehydes and Ketones

LI Jin-Heng*, LIAO Hua, LIANG Yun, YIN Du-Lin   

  1. (Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, College of Chemistry and Chemical
    Engineering, Hunan Normal University, Changsha 410081)
  • Received:2004-08-19 Revised:2005-06-16 Published:2005-11-30
  • Contact: LI Jin-Heng

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1667

被引次数

13

加入二氧化碳可以促进羰基化合物的烯丙基化反应. 实验结果表明: 在1.0 MPa的二氧化碳和2 equiv.的锡存在下, 以THF/H2O为反应介质, 芳香醛化合物与烯丙基溴可以顺利地发生烯丙基化反应得到较高的产率, 而芳香酮化合物和脂肪醛等与烯丙基溴反应只得到较低的产率.

关键词: 二氧化碳, 烯丙基化反应, 锡, 羰基化合物, 烯丙基溴

Carbon dioxide was found to promote allylation of aldehydes and ketones. The results showed that in the presence of 1.0 MPa of CO2, 2 equiv. of Sn, and THF/H2O, allylation of aromatic aldehydes with allyl bromide was carried out smoothly in good yields, whereas aromatic ketone and aliphatic aldehyde reacted with allyl bromide, respectively, to afford the corresponding products in low yields.

Key words: allyl bromide, tin, allylation reaction, aldehyde and ketone, carbon dioxide