Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1874-1890.DOI: 10.6023/cjoc201912031 Previous Articles     Next Articles


严沣a,b, 蔡爽a,b, 闻武a,b, 文蔚a,b, 李博解a, 汪连生a, 朱磊a,c   

  1. a 湖北工程学院化学与材料科学学院 湖北孝感 432000;
    b 湖北大学材料科学与工程学院 武汉 430062;
    c 华中科技大学生物无机化学与药物湖北省重点实验室 武汉 430074
  • 收稿日期:2019-12-22 修回日期:2020-04-05 发布日期:2020-04-17
  • 通讯作者: 李博解, 汪连生, 朱磊;;
  • 基金资助:

Recent Advances and Applications in N-Methylation of Amines and Imines

Yan Fenga,b, Cai Shuanga,b, Wen Wua,b, Wen Weia,b, Li Bojiea, Wang Lianshenga, Zhu Leia,c   

  1. a School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan, Hubei 432000;
    b School of Materials Science and Engineering, Hubei University, Wuhan 430062;
    c Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Huazhong University of Science and Technology, Wuhan 430074
  • Received:2019-12-22 Revised:2020-04-05 Published:2020-04-17
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21774029), the Hubei University Excellent Young and Middle-Aged Science and Technology Innovation Team Project (No. T201816), the Opening Fund of Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica (No. BCMM201805), the Natural Science Foundation of Xiaogan City (No. XGKJ201910047), the "Chutian Scholar" Program of Hubei Province (Lei Zhu), and the High-Level Master's Thesis Cultivation Project of Hubei Engineering University.

N-Methylation of amines and imines is one of the most important reactions for C-N bond formation. It is widely utilized for both laboratary research and industrial applications. Traditional methylation reactions involve the use of flammable, explosive and toxic starting materials. In contrast, newly developed methods have overcome this point and provide a mild strategy. In this transformation, C1 carbon source for the methyl group is important which determines the type of catalyst, reaction conditions and substrate scope. Herein, the research progress for the N-methylation of amines and imines is summarized based on different C1 carbon source.

Key words: N-methylation, carbon dioxide, formic acid, methanol, metal catalyst