有机化学 ›› 2018, Vol. 38 ›› Issue (1): 118-123.DOI: 10.6023/cjoc201708037 上一篇    下一篇

所属专题: 庆祝吴养洁院士九十华诞专辑

研究论文

联苯骨架手性双咪唑啉配体的合成及在不对称环丙烷化中的应用

朱新举, 牛俊龙, 赵雪梅, 郝新奇, 宋毛平   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2017-08-19 修回日期:2017-11-08 发布日期:2017-11-17
  • 通讯作者: 郝新奇, 宋毛平 E-mail:xqhao@zzu.edu.cn;mpsong@zzu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21528201,21672192)和中国博士后科学基金(No.2016M602254)资助项目.

Synthesis of Chiral Bis(imidazoline) Ligands with Biphenyl Backbone and Their Application in the Asymmetric Cyclopropanation Reaction

Zhu Xinju, Niu Junlong, Zhao Xuemei, Hao Xinqi, Song Maoping   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2017-08-19 Revised:2017-11-08 Published:2017-11-17
  • Contact: 10.6023/cjoc201708037 E-mail:xqhao@zzu.edu.cn;mpsong@zzu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21528201, 21672192) and the China Postdoctoral Science Foundation (No. 2016M602254).

一系列含有轴手性和中心手性的联苯双咪唑啉配体被首次合成.相较于传统的策略,Ullmann偶联方法表现出更高的反应效率,尤其对于含有叔丁基的配体.得到的配体被进一步应用于在铜催化下的不对称环丙烷化.

关键词: 咪唑啉, 轴手性, 中心手性, 不对称环丙烷化

A serial of biphenyl bisimidazolines containing both axial and central chirality have been synthesized for the first time. Compared with common method, Ullmann coupling methodology exhibited superior performance expecially for t-Bu substituted ligands. The obtained ligands were further applied in the Cu-catalyzed asymmetric cyclopropanation.

Key words: imidazoline, axial chirality, central chirality, asymmetric cyclopropanation