噌啉类化合物的合成研究进展

doi:10.6023/cjoc201806021

摘要/Abstract

噌啉类化合物具有抗癌、抗菌、抗病毒、抗炎和镇静作用等多种生物活性.此外，噌啉环还是优良的电子受体.因此，噌啉骨架已经成为新材料和新药研发中的优势骨架，其合成新方法的研究也受到了化学家们的持续关注.近年来，碳氢官能团化策略迅猛发展，大大推动了噌啉类化合物合成新方法的开发.按照不同的合成策略和反应底物进行分类，综述了近年来噌啉类化合物合成研究的最新进展.

关键词: 噌啉, 碳氢官能团化, 偶联, 串联反应

Cinnolines are "privileged scaffold" in new material and drug research, and development for their extensive biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory, and sedative activities and good electron-accepting ability. As a result, the development of new synthetic routes to this important structure has been actively investigated in recent years. Especially, the C-H functionalization strategy has promoted the development of new methods greatly. The recent advances of the synthetic methods to cinnolines based on different synthetic strategies and raw materials are reviewed.

Key words: cinnolines, C-H functionalization, coupling, tandem reaction

引用此文

苏琳, 侯卫. 噌啉类化合物的合成研究进展[J]. 有机化学, 2019, 39(2): 363-376.

Su Lin, Hou Wei. Progress in the Synthesis of Cinnoline Derivatives[J]. Chin. J. Org. Chem., 2019, 39(2): 363-376.

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